GREM1, gremlin 1, DAN family BMP antagonist, 26585

N. diseases: 179; N. variants: 8
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease CLINGEN GREM1 and POLE variants in hereditary colorectal cancer syndromes. 26493165 2016
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease CLINGEN GREM1 germline mutation screening in Ashkenazi Jewish patients with familial colorectal cancer. 25992589 2015
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease CLINGEN Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. 25419707 2015
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 GermlineCausalMutation disease ORPHANET Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. 22561515 2012
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease CLINGEN Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. 22561515 2012
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease CLINGEN Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients. 21128281 2011
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 GeneticVariation disease BEFREE Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. 18084292 2008
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease CLINGEN Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. 17881565 2007
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease CLINGEN The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein. 16545136 2006
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease CLINGEN An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome. 12696020 2003
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease GENOMICS_ENGLAND
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease GENOMICS_ENGLAND