Seizures
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We herein propose that limbic seizure activity up-regulates Npas4-homer1a signaling in the hippocampus, thereby contributing to epileptogenesis in mice.
|
29222951 |
2018 |
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
NPAS4 has been proposed as a therapeutic target not only for depression and neurodegenerative diseases associated with synaptic dysfunction but also for type 2 diabetes and pancreas transplantation.
|
29899116 |
2018 |
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
NPAS4 has been proposed as a therapeutic target not only for depression and neurodegenerative diseases associated with synaptic dysfunction but also for type 2 diabetes and pancreas transplantation.
|
29899116 |
2018 |
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Growth of Triple Negative and Progesterone Positive Breast Cancer Causes Oxidative Stress and Down-Regulates Neuroprotective Transcription Factor NPAS4 and NPAS4-Regulated Genes in Hippocampal Tissues of TumorGraft Mice-an Aging Connection.
|
29556248 |
2018 |
Convulsive Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The combination of fluorescence in situ hybridization and immunohistochemical analyses revealed that Homer1amRNA co-localized with the Npas4 protein after the convulsive seizure response.
|
29222951 |
2018 |
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, mice lacking Npas4 also show differences in some aspects of post-stroke sociability and anxiety.
|
27574128 |
2017 |
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Moreover, mice lacking Npas4 also show differences in some aspects of post-stroke sociability and anxiety.
|
27574128 |
2017 |
Status Epilepticus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunoprecipitation of Upf1-bound RNA from the cytoplasmic and synaptosomal compartments followed by RNA sequencing identified unique populations of NMD-associated transcripts and altered levels after status epilepticus, including known substrates such as Arc as well as novel targets including Inhba and Npas4.
|
28128343 |
2017 |
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Finally, we show that chronic treatment with the GABA enhancing drug sodium valproate during adolescence is sufficient to induce long-lasting recovery of the molecular and behavioral abnormalities observed in Npas4 deficient mice.
|
27993645 |
2017 |
Cerebral Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Neuronal Per-Arnt-Sim domain protein 4 (Npas4) is an activity-dependent transcription factor whose expression is induced in various brain insults, including cerebral ischemia.
|
26690124 |
2015 |
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, it was demonstrated that Npas4 indeed has a neuroprotective role in ischemic stroke and that Npas4 might be involved in modulating the cell death pathway and inflammatory response.
|
26690124 |
2015 |
Dwarfism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
De novo duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure.
|
22030050 |
2011 |
Premature Menopause
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in female patients can be associated with clinical manifestations of mental retardation in addition to short stature and premature ovarian failure.
|
22030050 |
2011 |
Mental Retardation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in female patients can be associated with clinical manifestations of mental retardation in addition to short stature and premature ovarian failure.
|
22030050 |
2011 |
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transfection of neuroblastoma cell lines with NXF-ARNT2 or SIM2-ARNT2 increased and decreased expression of RET, respectively.
|
20977903 |
2011 |
Ovarian Failure, Premature
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in female patients can be associated with clinical manifestations of mental retardation in addition to short stature and premature ovarian failure.
|
22030050 |
2011 |
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transfection of neuroblastoma cell lines with NXF-ARNT2 or SIM2-ARNT2 increased and decreased expression of RET, respectively.
|
20977903 |
2011 |
Intellectual Disability
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in female patients can be associated with clinical manifestations of mental retardation in addition to short stature and premature ovarian failure.
|
22030050 |
2011 |
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transfection of neuroblastoma cell lines with NXF-ARNT2 or SIM2-ARNT2 increased and decreased expression of RET, respectively.
|
20977903 |
2011 |