|
Abdominal Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal behavior
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Consistent with the behavioral changes, levels of DA and the metabolite dihydroxyphenylacetic acid (DOPAC) were elevated (by 98% and 65%, respectively) in the SN, but not the striatum of Ad-GDNF-injected rats.
|
9449424 |
1997 |
|
Abnormal behavior
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
A few association analyses between GDNF gene polymorphisms and psychiatric disorders such as schizophrenia, attention deficit hyperactivity disorder and drug abuse have also been published but little is known about any effects of these polymorphisms on mood characteristics such as anxiety and depression.
|
24324616 |
2013 |
|
Abnormal behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Evidence suggests that brain-derived neurotrophic factor (BDNF) and glial cell line -derived neurotrophic factor (GDNF) are important in the regulation of synaptic plasticity, which plays a key role in the cognitive processes in psychiatric disorders.
|
28342945 |
2017 |
|
Abnormal behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Effect of glial cell line-derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders.
|
24105724 |
2013 |
|
Abnormality of temperature regulation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acoustic Neuroma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-beta1/beta2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular schwannomas compared to peripheral nerves.
|
19937367 |
2010 |
|
Acromegaly
|
0.020 |
Biomarker
|
disease |
BEFREE |
Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly.
|
30975543 |
2019 |
|
Acromegaly
|
0.020 |
Biomarker
|
disease |
BEFREE |
Disruption of GDNF's survival function might constitute a new therapeutic route in acromegaly.
|
25137025 |
2014 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, glial cell line-derived neurotrophic factor (GDNF)/GDNF family receptor alpha 1, Ras/extracellular regulated protein kinases (ERK), and promyelocytic leukemia zinc finger (PLZF)/chemokine (C-X-C motif) receptor 4 (CXCR4) serve as potential regulatory pathways that respond to the changes in sertoli cells and the niche of male germ cells.
|
30335884 |
2018 |
|
Addictive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The identification of a GDNF-mediated, autoregulatory long-lasting feedback loop could have important implications for GDNF's potential value as a treatment for addiction and neurodegenerative diseases.
|
17023388 |
2006 |
|
Addictive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our result is in good agreement with previous data indicating the role of GDNF in certain substance addictions.
|
31446765 |
2019 |
|
Adducted thumb
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Adenovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Results showed that the EDNRB and GDNF genes were able to be expressed in primary culture of NSCs by adenovirus infection.
|
23512482 |
2013 |
|
Adrenal Gland Pheochromocytoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
GDNF exerts similar effects on human pheochromocytoma cells in primary cultures.
|
12139916 |
2002 |
|
Adrenal Gland Pheochromocytoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
RET, a transmembrane receptor tyrosine kinase and a receptor for the glial cell-derived neurotrophic factor family ligands, was one of the first oncogenes to be identified, and has been shown to be an oncogene in thyroid cancer and pheochromocytoma.
|
22751117 |
2013 |
|
Adrenal Gland Pheochromocytoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The RET-activating ligand GDNF was anti-apoptotic for mouse pheochromocytoma but not for PC12 cells.
|
19551609 |
2009 |
|
Adrenal Gland Pheochromocytoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that although GDNF mutations do not appear to have a major role in the pathogenesis of familial or sporadic phaeochromocytomas, allelic variation at the GDNF locus may modify phaeochromocytoma susceptibility.
|
9215674 |
1997 |
|
Adrenal Gland Pheochromocytoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.
|
10998441 |
2000 |
|
Adult Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Next, we showed by immunohistochemistry that the activated form of ATF2 (ATF-2pp) was highly expressed in six different BL samples.
|
15185015 |
2004 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
VEGF mediated GDNF-induced angiogenesis in human glioblastoma.
|
30176167 |
2018 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Pre-treatment of glioblastoma cell lines with GDNF but not the alternative ligand neurturin, promoted mitogenic behaviour and conferred chemoresistance to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
|
19138852 |
2009 |
|
Adult Glioblastoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Differential regulation of glial cell line-derived neurotrophic factor (GDNF) expression in human neuroblastoma and glioblastoma cell lines.
|
9972821 |
1999 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Moreover, GDNF modulates the rate of neuroblastoma (NB) and glioblastoma cancer cell proliferation.
|
28878618 |
2017 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis.
|
23344256 |
2013 |