Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Egr-1 and RNA POL II facilitate glioma cell GDNF transcription induced by histone hyperacetylation in promoter II.
|
28187447 |
2017 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GDNF-induced MMP-13 expression and glioma migration were attenuated by MEK/extracellular signal-regulating kinase (ERK) and c-Jun N-terminal protein kinase (JNK) inhibitors, as well as ERK and JNK dominant-negative mutants.
|
20615395 |
2010 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our experiments presented a new mechanism adopted by GDNF supporting glioma development and indicated a possible therapeutic potential via the inhibition of proN-cadherin/FGFR1 interaction.
|
29750313 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The differentially expressed proteins were annotated using Gene Ontology, and neuropilin-1 (NRP1) was identified as the putative GDNF receptor in glioma.
|
29088765 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, we could show that injection of GL261 mouse glioma cells with GDNF knockdown by shRNA into mouse brains resulted in reduced tumor expansion and improved survival as compared to injection of control cells.
|
23344256 |
2013 |
Glioma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Changes in transcriptional factor binding capacity resulting from promoter region methylation induce aberrantly high GDNF expression in human glioma.
|
23606280 |
2013 |
Glioma
|
0.400 |
Biomarker
|
disease |
CTD_human |
GDNF is overexpressed in glioblastoma cell lines and human gliomas.
|
19138852 |
2009 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, the mechanism by which GDNF promotes glioma cell migration and invasion through regulating the dispersion and location of the Golgi apparatus (GA) is described.
|
30695072 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Anti-GDNF antibody in conditioned media of glioma cells suppressed much of the migratory activity.
|
10077155 |
1999 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This overexpression of GDNF may be of biological relevance for proliferation of glial tumors in humans.
|
10672319 |
2000 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings reveal that GDNF interacts with the extracellular domain of proN-cadherin, which suggests that proN-cadherin mediates GDNF-induced glioma cell migration and invasion.
|
28212546 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results show that 50 ng/mL GDNF for 24 h significantly promotes U251 glioma cell proliferation and migration (P < 0.05).
|
29224008 |
2017 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, GDNF was later reported to be highly expressed in gliomas, especially in glioblastomas, and was demonstrated as a potent proliferation factor involved in the development and migration of gliomas.
|
30059726 |
2018 |