GDNF, glial cell derived neurotrophic factor, 2668

N. diseases: 409; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.650 Biomarker disease BEFREE RET, a transmembrane receptor tyrosine kinase and a receptor for the glial cell-derived neurotrophic factor family ligands, was one of the first oncogenes to be identified, and has been shown to be an oncogene in thyroid cancer and pheochromocytoma. 22751117 2013
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.650 Biomarker disease BEFREE The RET-activating ligand GDNF was anti-apoptotic for mouse pheochromocytoma but not for PC12 cells. 19551609 2009
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.650 Biomarker disease BEFREE GDNF exerts similar effects on human pheochromocytoma cells in primary cultures. 12139916 2002
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.650 Biomarker disease BEFREE Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas. 10998441 2000
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.650 GeneticVariation disease BEFREE These findings suggest that although GDNF mutations do not appear to have a major role in the pathogenesis of familial or sporadic phaeochromocytomas, allelic variation at the GDNF locus may modify phaeochromocytoma susceptibility. 9215674 1997
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.650 Biomarker disease CTD_human These findings suggest that although GDNF mutations do not appear to have a major role in the pathogenesis of familial or sporadic phaeochromocytomas, allelic variation at the GDNF locus may modify phaeochromocytoma susceptibility. 9215674 1997
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.650 GeneticVariation disease UNIPROT These findings suggest that although GDNF mutations do not appear to have a major role in the pathogenesis of familial or sporadic phaeochromocytomas, allelic variation at the GDNF locus may modify phaeochromocytoma susceptibility. 9215674 1997
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.650 Biomarker disease HPO