GDNF, glial cell derived neurotrophic factor, 2668

N. diseases: 409; N. variants: 13
Disease: Mechanical Allodynia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.310 Biomarker phenotype BEFREE We previously demonstrated that nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) were upregulated after lengthening contractions (LC) in exercised muscle through B2 bradykinin receptor activation and cyclooxygenase (COX)-2 upregulation, respectively, and that these trophic factors sensitized nociceptors resulting in mechanical hyperalgesia (delayed-onset muscle soreness, DOMS). 28759126 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.310 Biomarker phenotype CTD_human Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. 20457222 2010