|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunostaining was performed for Netrin-1 (deleted in colorectal carcinoma [DCC], UNC5A) and GDNF receptors (rearranged during transfection [Ret], glycosylphosphatidylinositol-linked cell surface receptors [GFRα1, GFRα2, GFRα3]).
|
30811036 |
2019 |
|
Dementia, Vascular
|
0.010 |
Biomarker
|
disease |
BEFREE |
The current study showed that GDNF/GFRα1/Ret signaling plays an essential role in the CCH induced VD.
|
31456664 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, glial cell line-derived neurotrophic factor (GDNF)/GDNF family receptor alpha 1, Ras/extracellular regulated protein kinases (ERK), and promyelocytic leukemia zinc finger (PLZF)/chemokine (C-X-C motif) receptor 4 (CXCR4) serve as potential regulatory pathways that respond to the changes in sertoli cells and the niche of male germ cells.
|
30335884 |
2018 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In conclusion, the SMN by down-regulating GDNF and its receptor gfrα1 expression inhibits GDNF-gfrα1 complex generation and consequently suppresses Bcl-6b expression.
|
30195499 |
2018 |
|
malignant neoplasm of breast staging
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, high expression of ST3GAL1 was associated with poor clinical outcome in patients with late stage breast cancer and high expression of both ST3GAL1 and GFRA1 adversely impacted outcome in those with high grade tumors.
|
30040982 |
2018 |
|
Promyelocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, glial cell line-derived neurotrophic factor (GDNF)/GDNF family receptor alpha 1, Ras/extracellular regulated protein kinases (ERK), and promyelocytic leukemia zinc finger (PLZF)/chemokine (C-X-C motif) receptor 4 (CXCR4) serve as potential regulatory pathways that respond to the changes in sertoli cells and the niche of male germ cells.
|
30335884 |
2018 |
|
Oestrogen receptor positive breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found GFRA1 to be a substrate of ST3GAL1-mediated O-linked sialylation, which is crucial to GDNF-induced signaling in ER-positive breast cancer cells.
|
30040982 |
2018 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because both GDNF and GFRα1 are secreted by nerves, we examined the role of RET signaling in prostate cancer.<b>Experimental Design:</b> Expression of RET, GDNF, and/or GFRα1 was assessed.
|
28490466 |
2017 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because both GDNF and GFRα1 are secreted by nerves, we examined the role of RET signaling in prostate cancer.<b>Experimental Design:</b> Expression of RET, GDNF, and/or GFRα1 was assessed.
|
28490466 |
2017 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, we conclude that circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. circGFRA1 may be a diagnostic biomarker and potential target for TNBC therapy.
|
29037220 |
2017 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, we conclude that circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. circGFRA1 may be a diagnostic biomarker and potential target for TNBC therapy.
|
29037220 |
2017 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that, in AD neurons, specific impairments of GFRα1, which may be linked to glutamatergic neurotransmission, shed light on developing potential therapeutic strategies for AD by upregulation of GFRα1 expression.
|
25253858 |
2014 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we aimed at characterizing the role of the neurotrophic factor neurturin (NRTN) and its receptor glial-cell-line-derived neurotrophic factor receptor alpha-2 (GFRα-2) in pancreatic cancer (PCa) and pancreatic neuropathy.
|
24067900 |
2014 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we aimed at characterizing the role of the neurotrophic factor neurturin (NRTN) and its receptor glial-cell-line-derived neurotrophic factor receptor alpha-2 (GFRα-2) in pancreatic cancer (PCa) and pancreatic neuropathy.
|
24067900 |
2014 |
|
Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we aimed at characterizing the role of the neurotrophic factor neurturin (NRTN) and its receptor glial-cell-line-derived neurotrophic factor receptor alpha-2 (GFRα-2) in pancreatic cancer (PCa) and pancreatic neuropathy.
|
24067900 |
2014 |
|
Breast Fibrocystic Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We determined the mRNA and protein expression of three proteins demonstrated to bind ARTN, namely GFRα1, GFRα3 and syndecan-3 (SDC3), in benign breast disease and mammary carcinoma by in situ hybridization and immunohistochemistry, respectively.
|
23351331 |
2013 |
|
Teratoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Despite some variability in genetic background in these crosses, this result is consistent with previous genetic mapping of teratoma susceptibility loci to the region containing Gfra1.
|
23473982 |
2013 |
|
Adult Teratoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Despite some variability in genetic background in these crosses, this result is consistent with previous genetic mapping of teratoma susceptibility loci to the region containing Gfra1.
|
23473982 |
2013 |
|
Childhood Teratoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Despite some variability in genetic background in these crosses, this result is consistent with previous genetic mapping of teratoma susceptibility loci to the region containing Gfra1.
|
23473982 |
2013 |
|
Venous Thromboembolism
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In stratified analyses, SNPs in the following genes were significantly associated with VTE: F5 and ABO among both genders and LY86 among women; F2, ABO and KLKB1 among FV Leiden non-carriers; F5, F11, KLKB1 and GFRA1 in those with ABO non-O blood type; and ABO, F5, F11, KLKB1, SCUBE1 and SELP among prothrombin G20210A non-carriers.
|
21463476 |
2011 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we showed that expression levels of intrinsic c-Ret, glial cell line-derived neurotrophic factor (Gdnf) and Gdnf receptor alpha 1 (Gfra1) transcripts in malignant melanomas from RET-transgenic mice were significantly upregulated compared with those in benign melanocytic tumors.
|
20422010 |
2010 |
|
Thyroid Nodule
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Elevated thyroid nodule risks were associated with the minor alleles of RET S836S (rs1800862, P = 0.03) and GFRA1 -193C>G (rs not assigned, P = 0.05) and decreased risk with XRCC1 rs1799782" genes_norm="7515">R194W (rs1799782, P trend = 0.03) and TGFB1 T263I (rs1800472, P = 0.009).
|
19138047 |
2009 |
|
Neoplasms, Germ Cell and Embryonal
|
0.010 |
Biomarker
|
group |
LHGDN |
Expression of glial cell line-derived neurotropic factor receptor alpha-1 in immature teratomas.
|
19019765 |
2008 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these SNPs and haplotypes located in the SCBY14, CRHR2, and GFRA1 genes will be used as markers to identify a subgroup of Japanese patients with chronic HCV infection who are at high risk of developing HCC.
|
16175604 |
2005 |
|
Liver carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these SNPs and haplotypes located in the SCBY14, CRHR2, and GFRA1 genes will be used as markers to identify a subgroup of Japanese patients with chronic HCV infection who are at high risk of developing HCC.
|
16175604 |
2005 |