FETUB, fetuin B, 26998

N. diseases: 38; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.060 AlteredExpression disease BEFREE Serum fetuin-B levels are higher in women with PCOS and are independently connected with HOMA-β and hepatic steatosis. 31307012 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.060 Biomarker disease BEFREE This study aims to investigate the role of fetuin B in hepatic steatosis in C57BL/6 mice and HepG2 cells. 30972177 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.060 AlteredExpression disease BEFREE In conclusion, despite the fact that the two hepatokines, fetuin-A and fetuin-B, are upregulated in the state of hepatic steatosis in humans, it appears that they differently impact on glucose homeostasis. 29138227 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.060 Biomarker disease BEFREE Fetuin B is an adipokine/hepatokine which is significantly elevated in insulin resistance/type 2 diabetes mellitus and hepatic steatosis. 29153939 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.060 Biomarker disease BEFREE Hepatokines are proteins that are secreted by hepatocytes, and many hepatokines have been linked to the induction of metabolic dysfunction, including fetuin A, fetuin B, retinol-binding protein 4 (RBP4) and selenoprotein P. In this Review, we describe the factors that influence the development of hepatic steatosis, provide evidence of strong links between hepatic steatosis and insulin resistance in non-hepatic tissues, and discuss recent advances in our understanding of how steatosis alters hepatokine secretion to influence metabolic phenotypes through inter-organ communication. 28621339 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.060 Biomarker disease BEFREE Targeted analysis showed that fetuin B was increased in humans with liver steatosis and patients with type 2 diabetes. 26603189 2015