Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
USP21 is the most frequently amplified deubiquitinase in BLBC patient tumors, and its amplification co-occurs with the upregulation of FOXM1 protein.
|
30865895 |
2019 |
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In the present study, tissue samples from normal liver, cirrhosis and HCC were subjected to differentially gene expression analysis, weighted gene correlation network analysis to identify the twenty hub genes (TOP2A, CDC20, PTTG1, CDCA5, CCNB2, PRC1, KIF20A, SF3B4, HSP90AB1, FOXD2, PLOD3, CCT3, SETDB1, VPS45, SPDL1, RACGAP1, MED24, KIAA0101, ZNF282, and USP21) in the pathological progression from cirrhosis to HCC.
|
31811111 |
2019 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth.
|
29706623 |
2018 |
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The results showed that the entire neddylation pathway, including NEDD8 (the IHC staining of NEDD8 represents the global-protein neddylation), E1 NEDD8-activating enzymes (NAE1 and UBA3), E2 NEDD8-conjugating enzymes (UBE2F and UBE2M), E3 NEDD8-ligases (MDM2, RBX1 and RNF7), and deneddylation enzymes (COPS5, UCHL1 and USP21), was overactivated in HCC.
|
29846044 |
2018 |
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
These findings indicate that USP21-mediated deubiquitination and stabilization of MEK2 play a critical role in HCC development.
|
29706623 |
2018 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In this study, we found that ubiquitin-specific protease (USP21) was upregulated in BC and the ectopic expression of USP21 was closely associated with tumor size and metastasis.
|
28223825 |
2017 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Together, our findings identify deubiquitination as a means to regulate BRCA2 function and point to USP21 as a potential therapeutic target in BRCA2-proficient tumors.BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress.
|
28743957 |
2017 |
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we show that USP21 is overexpressed in hepatocellular carcinoma, where it promotes BRCA2 stability and inversely correlates with patient survival.
|
28743957 |
2017 |
Liver Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, tissue samples from normal liver, cirrhosis and HCC were subjected to differentially gene expression analysis, weighted gene correlation network analysis to identify the twenty hub genes (TOP2A, CDC20, PTTG1, CDCA5, CCNB2, PRC1, KIF20A, SF3B4, HSP90AB1, FOXD2, PLOD3, CCT3, SETDB1, VPS45, SPDL1, RACGAP1, MED24, KIAA0101, ZNF282, and USP21) in the pathological progression from cirrhosis to HCC.
|
31811111 |
2019 |
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.
|
31488580 |
2019 |
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.
|
31488580 |
2019 |
Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, tissue samples from normal liver, cirrhosis and HCC were subjected to differentially gene expression analysis, weighted gene correlation network analysis to identify the twenty hub genes (TOP2A, CDC20, PTTG1, CDCA5, CCNB2, PRC1, KIF20A, SF3B4, HSP90AB1, FOXD2, PLOD3, CCT3, SETDB1, VPS45, SPDL1, RACGAP1, MED24, KIAA0101, ZNF282, and USP21) in the pathological progression from cirrhosis to HCC.
|
31811111 |
2019 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conversely, depletion of USP21 impairs PDAC tumor growth.
|
31488580 |
2019 |
Basal-Like Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, these data suggest a role for USP21 in the proliferation and potentially treatment of FOXM1-high, USP21-high BLBC.
|
30865895 |
2019 |
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data demonstrated that USP21 might play a crucial role in regulating BC progression and could provide a potential therapeutic strategy for BC.
|
28223825 |
2017 |
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data demonstrated that USP21 might play a crucial role in regulating BC progression and could provide a potential therapeutic strategy for BC.
|
28223825 |
2017 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Multiple function analysis such as CCK-8, colony formation, wound healing, and transwell analysis indicated that USP21 regulated cell proliferation and metastasis in bladder carcinoma cell lines.
|
28223825 |
2017 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Low expression of USP21 in early stage renal clear cell carcinoma suggests that USP21 may be a useful biomarker.
|
28969054 |
2017 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Together, our findings identify deubiquitination as a means to regulate BRCA2 function and point to USP21 as a potential therapeutic target in BRCA2-proficient tumors.BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress.
|
28743957 |
2017 |
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data demonstrated that USP21 might play a crucial role in regulating BC progression and could provide a potential therapeutic strategy for BC.
|
28223825 |
2017 |
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition, our search identified a cancer mutation that inactivates the NES of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus.
|
27174732 |
2016 |
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition, our search identified a cancer mutation that inactivates the NES of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus.
|
27174732 |
2016 |