|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
197 patients with UC and 302 with CD (499 with inflammatory bowel disease (IBD] whose disease started before age 20 years and whose age at time of study was less than 25 years were investigated, with two age- and sex-matched controls for each patient.
|
3685876 |
1987 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results do not support an exclusive association of P. maltophilia with Crohn's disease but rather suggest a possible association of P. maltophilia with IBD.
|
6854128 |
1983 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Predominant expression of the V delta 1 subtype was demonstrated in the small intestine of patients with coeliac disease and in the inflamed colon of patients with inflammatory bowel diseases (IBD: ulcerative colitis and Crohn's disease) as well as in colon biopsies taken from macroscopically normal areas of colon.
|
7813110 |
1995 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The nine hour overnight urinary excretion of polyethyleneglycol-400 (PEG-400) and three inert sugars (lactulose, l-rhamnose, and mannitol) was used to test the permeation in 47 patients with Crohn's disease of whom 18 had at least one first degree relative with inflammatory bowel disease (2BD) and 52 patients with ulcerative colitis of whom 16 had at least one first degree relative with IBD.
|
8307453 |
1994 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using the MAPMAKER/SIBS program, the segregation of 21 microsatellite marker loci spanning the 4 putative IBD gene loci was analyzed in a study population comprising 161 families with 114 Crohn's disease, 36 ulcerative colitis, and 50 mixed IBD sibling pairs from the Greater Toronto area.
|
9797358 |
1998 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, sib pairs who are discordant for both smoking and IBD type almost always show CD in the smoker and UC in the non-smoker, and so in some cases tobacco consumption acts on IBD genetic predisposition to shift the phenotype from UC towards CD.
|
12077086 |
2002 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The future discovery of other IBD genetic risk factors, facilitated by the completion of the human genome sequencing and annotation, may allow the development of better therapies, possibly including preventive therapies, for patients with Crohn's disease and ulcerative colitis.
|
12122744 |
2002 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Crohn's and chronic ulcerative colitis- collectively known as inflammatory bowel disease [IBD]) are a very significant public health problem in the United States and other industrialized nations.
|
12664590 |
2002 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multiple factors, particularly IBD family history, tobacco use, age at diagnosis and recently, NOD2 mutant genotypes may influence Crohn's disease (CD) heterogeneity.
|
14555911 |
2003 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present data indicate that CTGF plays a different role in IBD and might be useful, especially in those cases with unusual disease presentation, to better differentiate UC and CD.
|
15256831 |
2004 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data support linkage for CD at 19p13 and suggest that the amino acid polymorphisms in ICAM-1 may be associated with IBD.
|
15290909 |
2004 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Organic cation transporter gene cluster variants may confer susceptibility to both CD and UC, and the TC haplotype may influence some clinical features of IBD, but does not interact with CARD15 variants.
|
16441470 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent advances in the field of inflammatory bowel disease (IBD) genetics have enabled the definition and refinement of multiple IBD susceptibility loci and the identification of gene variants within such regions showing association with Crohn's disease (CD) and/or ulcerative colitis (UC).
|
16679026 |
2006 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we review general aspects of IBD genetics with particular focus on the role of Nod2 in CD.
|
16987083 |
2007 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Families with IBD should be counseled that early tobacco use significantly increases the risk of developing CD or, if an ex-smoker, UC at a young age.
|
17345609 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed ATG16L1, a recently identified Crohn's disease (CD) susceptibility gene, in a large cohort with inflammatory bowel disease (IBD) including potential interactions with other IBD genes as well as factors regulating its gene expression.
|
18162085 |
2008 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multivariate analysis showed independent CD association for carriers of ATG16L1 (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.09-3.24), IBD5-IGR2230 (OR = 2.16, 95% CI 1.30-3.59), and IL23R-rs10889677 (OR = 2.13, 95% CI 1.39-3.28) while retaining association for NOD2 mutation carriers (OR = 4.45, 95% CI 2.68-7.38), IBD family history (OR = 2.75, 95% CI 1.42-5.31), tobacco (OR = 2.06, 95% CI 1.35-3.14), and Jewish ethnicity (OR = 20.1, 95% CI 2.16-186.8).
|
18521914 |
2008 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The adjusted multivariate logistic analyses revealed that the risk for CD of the pouch was increased in patients with a family history of CD, with an odds ratio (OR) of 3.22 (95% confidence interval [CI] 1.56-6.67), or with a first-degree relative with CD (OR = 4.18, 95% CI, 1.48-11.8), or with a greater number of family members with CD (OR = 2.00 per family member, 95% CI, 1.19-3.37), adjusting for age, gender, smoking status, duration of IBD, duration of having a pouch, and a preoperation diagnosis of indeterminate colitis or CD.
|
18798573 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MATERIELS AND METHODS: SNPs at positions -627 (C > A) and -1117 (G > A) in the IL-10 promoter were determined in a sample of 105 Tunisian patients with IBD (75 CD and 30 UC) and 90 matched healthy controls.
|
19184348 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of recently completed genome-wide association studies have advanced knowledge of inflammatory bowel disease (IBD) genetics, including the identification of over 30 genes or loci associated with Crohn's disease (CD).
|
19436278 |
2009 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inflammatory bowel diseases [IBD], ulcerative colitis [UC] and Crohn's disease [CD], are chronic intestinal disorders of unknown etiology.
|
19519444 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most significant finding in the IBD research has been identification of mutations in the gene that encodes Nod2 (nucleotide-binding oligomerization domain 2) protein in a subgroup of patients with Crohn's disease.
|
19723304 |
2009 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genotype 2DL2+/HLA-C lys(80)+ was also more common in controls (IBD: p = 0.005; UC: p = 0.01; CD: p = NS); as well as 2DL1+/HLA-C Asn(80)+ (IBD: p = 0.026; UC: p = NS;CD: p = NS).
|
20036705 |
2010 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that colonic inflammation in Il10-/- mice inoculated with solutions containing Enterococcus strains is associated with gene expression changes similar to those of human IBD, specifically CD, and that with the EF.CIF inoculum in particular this is an appropriate model to investigate food-gene interactions relevant to human CD.
|
20630110 |
2010 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Firmicutes were reduced in IBD samples and there were concurrent increases in Bacteroidetes, and in CD only, Enterobacteriaceae.
|
21219646 |
2011 |