|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
197 patients with UC and 302 with CD (499 with inflammatory bowel disease (IBD] whose disease started before age 20 years and whose age at time of study was less than 25 years were investigated, with two age- and sex-matched controls for each patient.
|
3685876 |
1987 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Predominant expression of the V delta 1 subtype was demonstrated in the small intestine of patients with coeliac disease and in the inflamed colon of patients with inflammatory bowel diseases (IBD: ulcerative colitis and Crohn's disease) as well as in colon biopsies taken from macroscopically normal areas of colon.
|
7813110 |
1995 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The nine hour overnight urinary excretion of polyethyleneglycol-400 (PEG-400) and three inert sugars (lactulose, l-rhamnose, and mannitol) was used to test the permeation in 47 patients with Crohn's disease of whom 18 had at least one first degree relative with inflammatory bowel disease (2BD) and 52 patients with ulcerative colitis of whom 16 had at least one first degree relative with IBD.
|
8307453 |
1994 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, sib pairs who are discordant for both smoking and IBD type almost always show CD in the smoker and UC in the non-smoker, and so in some cases tobacco consumption acts on IBD genetic predisposition to shift the phenotype from UC towards CD.
|
12077086 |
2002 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The future discovery of other IBD genetic risk factors, facilitated by the completion of the human genome sequencing and annotation, may allow the development of better therapies, possibly including preventive therapies, for patients with Crohn's disease and ulcerative colitis.
|
12122744 |
2002 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A family history of IBD was present in 3.4 % in UC and 9.9 % in CD patients.
|
14760767 |
2004 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present data indicate that CTGF plays a different role in IBD and might be useful, especially in those cases with unusual disease presentation, to better differentiate UC and CD.
|
15256831 |
2004 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The inflammatory bowel disease linkage peak on chromosome 6q is located in the same general region that showed nominal evidence for linkage to IBD in a Belgian genome scan, and the ulcerative colitis linkage peak on chromosome 2q is located in the same general region that showed nominal evidence for linkage to the inflammatory bowel disease, Crohn's disease, or ulcerative colitis phenotypes in four other European/North American genome scans.
|
15472510 |
2004 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Organic cation transporter gene cluster variants may confer susceptibility to both CD and UC, and the TC haplotype may influence some clinical features of IBD, but does not interact with CARD15 variants.
|
16441470 |
2006 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent advances in the field of inflammatory bowel disease (IBD) genetics have enabled the definition and refinement of multiple IBD susceptibility loci and the identification of gene variants within such regions showing association with Crohn's disease (CD) and/or ulcerative colitis (UC).
|
16679026 |
2006 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD (N = 232) and UC (N = 121) subjects were ascertained from our population-based IBD Registry derived from Manitoba Health, the single provincial insurer.
|
17100976 |
2007 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Families with IBD should be counseled that early tobacco use significantly increases the risk of developing CD or, if an ex-smoker, UC at a young age.
|
17345609 |
2007 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we review the up-to-date studies on the genetic basis for IBD and explore the newly described UC-associated apical junction complex pointing to a primary defect in barrier defense.
|
18598228 |
2008 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genotype 2DL2+/HLA-C lys(80)+ was also more common in controls (IBD: p = 0.005; UC: p = 0.01; CD: p = NS); as well as 2DL1+/HLA-C Asn(80)+ (IBD: p = 0.026; UC: p = NS;CD: p = NS).
|
20036705 |
2010 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To do a genome-wide gene expression study of active and inactive ulcerative colitis and Crohn's disease (inflammatory bowel disease--IBD) and examine the most differentially expressed genes.
|
21992413 |
2011 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWAS) in several populations have demonstrated significant association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)) and psoriasis, suggesting that perturbation of the IL-23 signaling pathway is relevant to the pathophysiology of these diseases.
|
22022372 |
2011 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IBD-CRN cases included 17 with ulcerative colitis (UC) and two with Crohn's disease (CD); nine had cancer and 10 had dysplasia.
|
23347191 |
2013 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease.
|
23348120 |
2013 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies identified the autophagy gene IRGM to be strongly associated with Crohn's disease (CD) but its impact in ulcerative colitis (UC), its phenotypic effects and potential epistatic interactions with other IBD susceptibility genes are less clear which we therefore analyzed in this study.
|
23365659 |
2013 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expanding knowledge of the role of genetic variants involved in the susceptibility to IBD heralds an era of disease categorization beyond Crohn's disease and ulcerative colitis.
|
24345887 |
2014 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRPA1 and TRPV1 expressions were investigated in human colon biopsies of healthy subjects and patients with inflammatory bowel diseases (IBD: ulcerative colitis, Crohn's disease) with quantitative PCR and immunohistochemistry.
|
25265225 |
2014 |
|
Ulcerative Colitis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The epigenetic changes observed in this study indicate that CD and UC exhibit specific DNA methylation signatures with potential clinical applications in IBD non-invasive diagnosis and prognosis.
|
25526479 |
2014 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These novel approaches are fully applicable to IBD and allow us to achieve the ultimate goal of developing and applying personalized medicine and far more effective therapies to individual patients with Crohn's disease and ulcerative colitis.
|
25531360 |
2014 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dermatological assessment was performed in 251 IBD patients [115 females, age 47 [16-85]; IBD duration 9 years [1-46]]: 158 Crohn's disease [CD] [63%], 93 ulcerative colitis [UC] [37%].
|
25908719 |
2015 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IBD (Crohn's disease and Ulcerative Colitis) is chronic and multifactorial disease of the gastrointestinal tract.
|
25910289 |
2014 |