GJB1, gap junction protein beta 1, 2705

N. diseases: 28; N. variants: 85
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.300 Biomarker disease CTD_human Downregulation of connexin 32 attenuates hypoxia/reoxygenation injury in liver cells. 25530438 2015
CUI: C0019207
Disease: Hepatoma, Morris
Hepatoma, Morris 		0.300 Biomarker disease CTD_human Tumor promotion in liver of mice with a conditional Cx26 knockout. 18308698 2008
CUI: C0019208
Disease: Hepatoma, Novikoff
Hepatoma, Novikoff 		0.300 Biomarker disease CTD_human Tumor promotion in liver of mice with a conditional Cx26 knockout. 18308698 2008
CUI: C0086404
Disease: Experimental Hepatoma
Experimental Hepatoma 		0.300 Biomarker disease CTD_human Tumor promotion in liver of mice with a conditional Cx26 knockout. 18308698 2008
CUI: C1266042
Disease: Chromophobe Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. 18264126 2008
CUI: C1266043
Disease: Sarcomatoid Renal Cell Carcinoma
Sarcomatoid Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. 18264126 2008
CUI: C1266044
Disease: Collecting Duct Carcinoma of the Kidney
Collecting Duct Carcinoma of the Kidney 		0.300 Biomarker disease CTD_human 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. 18264126 2008
CUI: C1306837
Disease: Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. 18264126 2008
CUI: C0001430
Disease: Adenoma
Adenoma 		0.300 Biomarker group CTD_human Surprisingly, in lung adenomas Cx32 and Cx43 expressions were not detected, although the expression of connexins 26 and 46 was present. 16926031 2006
CUI: C0205646
Disease: Adenoma, Basal Cell
Adenoma, Basal Cell 		0.300 Biomarker disease CTD_human Altered expression of connexins in urethane-induced mouse lung adenomas. 16926031 2006
CUI: C0205647
Disease: Follicular adenoma
Follicular adenoma 		0.300 Biomarker disease CTD_human Altered expression of connexins in urethane-induced mouse lung adenomas. 16926031 2006
CUI: C0205648
Disease: Adenoma, Microcystic
Adenoma, Microcystic 		0.300 Biomarker disease CTD_human Altered expression of connexins in urethane-induced mouse lung adenomas. 16926031 2006
CUI: C0205649
Disease: Adenoma, Monomorphic
Adenoma, Monomorphic 		0.300 Biomarker disease CTD_human Altered expression of connexins in urethane-induced mouse lung adenomas. 16926031 2006
CUI: C0205650
Disease: Papillary adenoma
Papillary adenoma 		0.300 Biomarker disease CTD_human Altered expression of connexins in urethane-induced mouse lung adenomas. 16926031 2006
CUI: C0205651
Disease: Adenoma, Trabecular
Adenoma, Trabecular 		0.300 Biomarker disease CTD_human Altered expression of connexins in urethane-induced mouse lung adenomas. 16926031 2006
CUI: C0032927
Disease: Precancerous Conditions
Precancerous Conditions 		0.300 Biomarker group CTD_human Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis. 2559087 1989
CUI: C0282313
Disease: Condition, Preneoplastic
Condition, Preneoplastic 		0.300 Biomarker disease CTD_human Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis. 2559087 1989
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.300 Biomarker disease CTD_human Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis. 2559087 1989
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.310 Biomarker group CTD_human These results may indicate a role of Cx32 and Cx43 in urethane-induced lung carcinogenesis, since their absence may contribute to the development of urethane induced lung tumors. 16926031 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.310 Biomarker disease CTD_human Altered expression of connexins in urethane-induced mouse lung adenomas. 16926031 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.310 Biomarker group CTD_human Cx32-deficient nontumorous lung tissue exhibited an increased proliferative index (P < 0.001), and, after exposure to the carcinogen diethylnitrosamine, Cx32-deficient mice exhibited a highly statistically significant (P < 0.001) increase in bronchioloalveolar lung tumor incidence (28 of 45, 62%) and a 45% increase in average multiplicity compared with wild-type mice (7 of 29, 24%). 15492231 2004
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.310 Biomarker disease CTD_human The gap junction protein connexin32 is a mouse lung tumor suppressor. 15492231 2004
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 Biomarker phenotype CTD_human The second experiment focused on the effects of Cx32 disruption on metastasis by HCCs induced by administration of DEN and N-nitrosomorpholine. 17978847 2007
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.370 Biomarker group CTD_human A rat liver gap junction (GJ) cDNA probe that detects mRNA encoding the 32 Kd GJ-protein (connexin 32) was employed to study GJ-protein gene expression in rat liver tumors induced by a single exposure to diethylnitrosamine (DEN) followed by exposure to 2-acetylaminofluorene (AAF)/CCl4/AAF or induced by systemic administration of N-ethyl-N-hydroxyethylnitrosamine (EHEN). 2559087 1989
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.400 Biomarker disease CTD_human This finding suggests that treatment with 5-aza-CdR could be a new effective therapy against human metastatic RCC and that Cx32 could be a potential target for the treatment of RCC. 18264126 2008