|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
ANKRD1 was expressed in the majority of ovarian adenocarcinomas tested (62/71, 87%), and higher tumor levels of ANKRD1 were found in patients with worse outcome (overall survival, P=0.013).
|
18980987 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
We found that CARP was aberrantly expressed in atrophic skeletal muscle fibers in ALS.
|
12679596 |
2003 |
|
Arrhythmogenic Right Ventricular Dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Regression analysis showed a positive correlation between CARP and proANP in ARVC failing hearts.
|
19359327 |
2009 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
There are no reports on CARPs in human astrocytomas or oligodendroglial tumors.
|
29792187 |
2018 |
|
Ataxia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish.
|
23087022 |
2013 |
|
Atrial Septal Defect Sinus Venosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
ANKRD1 transgenic mice present sinus venosus defect, which originates during development by impaired remodeling of early embryonic heart.
|
31688894 |
2019 |
|
Breast adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Congener- and concentration-dependent antagonism of 17beta-estradiol (E2)-induced gene expression, rather than induction of ER-dependent gene expression, was observed for the MeSO(2)-PCBs on lucifierase activity in stably transfected human breast adenocarcinoma T47D cells (ER-CALUX) and vitellogenin (vtg) production in primary hepatocytes from male carp fish (Cyprinus carpio) (CARP-HEP/vtg).
|
12377985 |
2002 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, more studies concerning role of CARPs in oncogenesis are needed.
|
29792187 |
2018 |
|
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Ankyrin Repeat Domain 1 Overexpression is Associated with Common Resistance to Afatinib and Osimertinib in EGFR-mutant Lung Cancer.
|
30291293 |
2018 |
|
Cardiomegaly
|
0.200 |
Biomarker
|
phenotype |
RGD |
Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter.
|
10904011 |
2000 |
|
Cardiomyopathies
|
0.320 |
Biomarker
|
group |
GENOMICS_ENGLAND |
|
|
|
|
Cardiomyopathies
|
0.320 |
Biomarker
|
group |
BEFREE |
Importantly, cardiac ANKRD1 has been shown to be highly induced in various cardiomyopathies and in heart failure, although it is still unclear what impact this may have on the pathophysiology of heart failure.
|
28672880 |
2017 |
|
Cardiomyopathies
|
0.320 |
GeneticVariation
|
group |
BEFREE |
Increased ANKRD1 levels linked to gain of function mutations have been associated to total anomalous pulmonary venous return and adult cardiomyopathy occurrence in humans.
|
31688894 |
2019 |
|
Cardiomyopathy, Dilated
|
0.130 |
Biomarker
|
group |
BEFREE |
MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy.
|
27353086 |
2016 |
|
Cardiomyopathy, Dilated
|
0.130 |
Biomarker
|
group |
BEFREE |
We evaluated ankyrin repeat domain 1 (ANKRD1), the gene encoding cardiac ankyrin repeat protein (CARP), as a novel candidate gene for dilated cardiomyopathy (DCM) through mutation analysis of a cohort of familial or idiopathic DCM patients, based on the hypothesis that inherited dysfunction of mechanical stretch-based signaling is present in a subset of DCM patients.
|
19608030 |
2009 |
|
Cardiomyopathy, Dilated
|
0.130 |
Biomarker
|
group |
HPO |
|
|
|
|
Cardiomyopathy, Dilated
|
0.130 |
GeneticVariation
|
group |
BEFREE |
Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy.
|
19525294 |
2009 |
|
Cardiomyopathy, Familial Idiopathic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
On the basis of genetic and functional analysis of CARP mutations, we have identified ANKRD1 as a new gene associated with DCM, accounting for approximately 2% of cases.
|
19525294 |
2009 |
|
Cardiomyopathy, Familial Idiopathic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
According to our epidemiological data, the prevalence of ANKRD1 mutations seems to be lower than that of its binding partner myopalladin, indicating the clinical significance of myopalladin for the functional integrity of the sarcomeric apparatus and the protection against DCM.
|
22892539 |
2013 |
|
Cardiomyopathy, Familial Idiopathic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The ANKRD1 mutations may cause DCM as a result of disruption of the normal cardiac stretch-based signaling.
|
19608030 |
2009 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The current views on the actions of ANKRD1 in cardiovascular disease and its utility as a candidate cardiac biomarker with diagnostic and/or prognostic potential are also discussed.
|
28672880 |
2017 |
|
Cardiovascular Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now.
|
27143260 |
2016 |
|
Cerebellar Ataxia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish.
|
23087022 |
2013 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Cationic arginine-rich and poly-arginine peptides (referred to as CARPs) have potent neuroprotective properties in in vitro excitotoxicity and in vivo models of stroke.
|
29177102 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We identified two regions in MUC2 promoter, region A (-289 and -274) and region C (-193 and -160), that correlated with loss of MUC2 expression by comparing the methylation status in 13 CRC cell lines with no or low MUC2 expression and those in 4 cell lines with high MUC2 expression.
|
20198318 |
2010 |