To our knowledge, our findings provide new insights into the roles of KLRG1 and CD57 expression in human T cells, forming the basis for a refined model of CD8<sup>+</sup> T cell differentiation during CMV infection.
A population of Natural Killer (NK) cells expressing the activating receptor NKG2C and the maturation marker CD57 expands in response to human cytomegalovirus (HCMV) infection.
Whereas, FcRγ<sup>neg</sup> NK cells in CMV infection are reported to express increased levels of the maturation marker CD57, the FcRγ<sup>neg</sup> NK cells observed in our CMV-negative vaccine cohort express less CD57 than their FcRγ<sup>+</sup> counterparts.
We extend previous observations of the impact of CMV on CD8<sup>+</sup> T cell functionality to the CD4<sup>+</sup> T cell compartment, revealing CD57 as a polyfunctionality marker of T cells which expands after CMV infection.
With a mediation analysis we demonstrated that cytomegalovirus (CMV) infection, which is an important driving force of immunosenescence, largely accounted for elevated CD57 expression observed in ELA.
As chronic cytomegalovirus (CMV) infection is probably one of the major driving forces of immunosenescence, and its persistent infection results in functional and phenotypic changes to the T-cell repertoire, the aim of this study was to analyze the effect of CMV-seropositivity and aging on the expression of CD300a and CD161 inhibitory receptors, along with the expression of CD57 marker on CD4<sup>+</sup>, CD8<sup>+</sup>, CD8<sup>+</sup>CD56<sup>+</sup> (NKT-Like) and CD4<sup>-</sup>CD8<sup>-</sup> (DN) T-cell subsets.
We here studied whether subclinical CD is associated with changes in blood CD57-expressing and Vδ1-expressing lymphocytes in children, and whether cytomegalovirus (CMV) infection modifies this association.
Unlike cytomegalovirus (CMV) infection and aging, human immunodeficiency virus (HIV) decreases the proportion of CD28(-)CD8(+) T cells expressing CD57.
In this article, we describe a case of transient monoclonal CD8+/CD57+ T-cell lymphocytosis with large granular lymphocyte (LGL) morphology occurring after primary CMV infection and review cases of virus-associated monoclonal CD8+ T-cell expansions reported in the literature.