BBC3, BCL2 binding component 3, 27113

N. diseases: 157; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.090 Biomarker disease BEFREE PUMA induces the rapid apoptosis of colorectal cancer cells. 11463391 2001
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.060 Biomarker disease BEFREE PUMA induces the rapid apoptosis of colorectal cancer cells. 11463391 2001
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE These results suggest that the balance between PUMA and p21 is pivotal in determining the responses to p53 activation and provide a model for understanding the basis of p53 mutations in human cancer. 12574499 2003
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 GeneticVariation group BEFREE These results suggest that the balance between PUMA and p21 is pivotal in determining the responses to p53 activation and provide a model for understanding the basis of p53 mutations in human cancer. 12574499 2003
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.060 Biomarker group LHGDN PUMA mediates the apoptotic response to p53 in colorectal cancer cells. 12574499 2003
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.210 Biomarker disease RGD Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. 12913114 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE We then sequenced the entire coding region of the PUMA gene in all the 30 primary tumors and in 10 head/neck cancer cell lines. 12963126 2003
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.090 Biomarker disease BEFREE The PUMA gene was mapped to chromosomal arm 19q, a region frequently deleted in head/neck and lung cancers. 12963126 2003
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE Although PUMA suppresses tumor cell growth in head/neck cancer, it does not appear to be a direct target of inactivation in head and neck tumorigenesis. 12963126 2003
CUI: C0278996
Disease: Malignant Head and Neck Neoplasm
Malignant Head and Neck Neoplasm 		0.030 Biomarker disease BEFREE PUMA in head and neck cancer. 12963126 2003
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.030 Biomarker disease BEFREE PUMA in head and neck cancer. 12963126 2003
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms 		0.010 AlteredExpression group LHGDN PUMA in head and neck cancer. 12963126 2003
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.060 AlteredExpression group LHGDN mRNA and protein expression of PUMA in sporadic colorectal cancer. 15547745 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE We show that weak PUMA expression in melanoma correlates with poorer overall and disease-specific 5-year survival (P<0.005 and P<0.001, respectively) of melanoma patients and that PUMA expression in tumor tissue is an independent predictor of both overall and disease-specific 5-year survival (P=0.05). 15690057 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE Our results suggest that PUMA expression may be an important prognostic marker for human melanoma and that adenoviral delivery of PUMA sensitizes melanoma cells to apoptosis. 15690057 2005
CUI: C0205748
Disease: Dysplastic Nevus
Dysplastic Nevus 		0.010 AlteredExpression disease BEFREE Here we report that PUMA expression is significantly weaker in primary melanomas compared to dysplastic nevi (P<0.0001), and is further reduced in metastatic melanomas compared to primary tumors (P=0.001). 15690057 2005
CUI: C3714514
Disease: Infection
Infection 		0.010 Biomarker group LHGDN Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis. 15731037 2005
CUI: C3495949
Disease: Locally advanced breast cancer
Locally advanced breast cancer 		0.010 Biomarker disease BEFREE Induction of p53 up-regulated modulator of apoptosis messenger RNA by chemotherapeutic treatment of locally advanced breast cancer. 15756011 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.070 Biomarker disease BEFREE DeltaNp73 antisense activates PUMA and induces apoptosis in neuroblastoma cells. 15803372 2005
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.070 Biomarker disease BEFREE DeltaNp73 antisense activates PUMA and induces apoptosis in neuroblastoma cells. 15803372 2005
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.070 Biomarker disease BEFREE DeltaNp73 antisense activates PUMA and induces apoptosis in neuroblastoma cells. 15803372 2005
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Moreover, exogenous expression of PUMA under the hTERT promoter system significantly suppressed the growth of subcutaneous U87-MG tumors in nude mice and did not induce apoptosis in surrounding nontumor tissues. 15960600 2005
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma 		0.010 AlteredExpression disease BEFREE These results indicate that PUMA, which is regulated under a tumor-specific expression system such as the hTERT promoter, may be better than p53 as a therapeutic tool for malignant gliomas. 15960600 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.070 Biomarker disease BEFREE Finally we demonstrated that BBC3 alone is sufficient to induce cell death in the 4-HPR-sensitive and resistant NB cell lines, and that siRNA against BBC3 significantly decreases apoptosis induced by 4-HPR. 16091745 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.070 Biomarker disease LHGDN Our results indicate that BBC3 mediates cell death in NB cells in response to 4-HPR. 16091745 2005