GLA, galactosidase alpha, 2717

N. diseases: 190; N. variants: 203
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain
0.100 Biomarker phenotype HPO
CUI: C4021662
Disease: Abnormal endocardium morphology
Abnormal endocardium morphology
0.100 Biomarker phenotype HPO
CUI: C3164445
Disease: Abnormality of aortic valve
Abnormality of aortic valve
0.100 Biomarker disease HPO
CUI: C4021750
Disease: Abnormality of femur morphology
Abnormality of femur morphology
0.100 Biomarker disease HPO
CUI: C0234221
Disease: Acroparesthesia
Acroparesthesia
0.010 GeneticVariation disease BEFREE Classic Fabry disease, an X-linked recessive lysosomal storage disease due to the deficient activity of alpha-galactosidase A, typically presents in early childhood with acroparesthesias, angiokeratomas, hypohidrosis, and corneal dystrophy. 16533976 2006
CUI: C0264714
Disease: Acute heart failure
Acute heart failure
0.010 AlteredExpression disease BEFREE The GALA study: relationship between galectin-3 serum levels and short- and long-term outcomes of patients with acute heart failure. 28406038 2017
CUI: C3850141
Disease: Acute-On-Chronic Liver Failure
Acute-On-Chronic Liver Failure
0.010 Biomarker disease BEFREE In this review, we discuss the mechanisms related to the alteration of the GLA and their involvement in ACLF pathogenesis and suggest some possible therapeutic options that could modulate the GLA dysfunction. 29200007 2018
CUI: C0001883
Disease: Airway Obstruction
Airway Obstruction
0.010 GeneticVariation group BEFREE PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort. 28543872 2017
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease HPO
CUI: C0002962
Disease: Angina Pectoris
Angina Pectoris
0.100 Biomarker phenotype HPO
CUI: C0002985
Disease: Angiokeratoma
Angiokeratoma
0.410 Biomarker disease HPO
CUI: C0002985
Disease: Angiokeratoma
Angiokeratoma
0.410 AlteredExpression disease BEFREE Family A men had markedly decreased α-GalA activity and childhood-onset classic manifestations, except for angiokeratoma and cornea verticillata. 28798024 2017
CUI: C0002985
Disease: Angiokeratoma
Angiokeratoma
0.410 Therapeutic disease CTD_human Angiokeratoma regression in a Fabry disease after treatment with agalsidase-beta: clinical effectiveness marker? 19925601 2010
CUI: C0003123
Disease: Anorexia
Anorexia
0.100 Biomarker disease HPO
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease HPO
CUI: C0003862
Disease: Arthralgia
Arthralgia
0.100 Biomarker phenotype HPO
CUI: C0003864
Disease: Arthritis
Arthritis
0.100 Biomarker disease HPO
CUI: C0004096
Disease: Asthma
Asthma
0.010 Biomarker disease BEFREE Perceived Discrimination Associated With Asthma and Related Outcomes in Minority Youth: The GALA II and SAGE II Studies. 27916618 2017
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation
0.010 Biomarker disease BEFREE Co-administration of HIV-MVA with rgp140/GLA-AF significantly enhanced antibody responses. 30496299 2018
CUI: C0004245
Disease: Atrioventricular Block
Atrioventricular Block
0.100 Biomarker disease HPO
CUI: C1145628
Disease: Autonomic nervous system disorders
Autonomic nervous system disorders
0.010 GeneticVariation group BEFREE Fabry's disease is an X-linked lysosomal storage disorder caused by α-galactosidase A gene mutations; neurological manifestations include cerebrovascular accidents, small-fibre neuropathy and autonomic dysfunction. 24380807 2014
CUI: C0004604
Disease: Back Pain
Back Pain
0.020 Biomarker phenotype BEFREE The aim of this paper is to present the development, theories, and underlying evidence for 'GLA:D Back' - a group education and exercise program that translates guideline recommendations into a clinician-delivered program for the promotion of self-management in people with persistent/recurrent back pain. 30497440 2018
CUI: C0004604
Disease: Back Pain
Back Pain
0.020 Biomarker phenotype BEFREE GLA:D<sup>®</sup> Back: implementation of group-based patient education integrated with exercises to support self-management of back pain - protocol for a hybrid effectiveness-implementation study. 30777049 2019
CUI: C0085166
Disease: Bacterial Vaginosis
Bacterial Vaginosis
0.020 GeneticVariation disease BEFREE The aim of the current double blind, randomised clinical trial was to assess the efficacy of a probiotic mixture, including Lactobacillus acidophilus GLA-14 and Lactobacillus rhamnosus HN001, in combination with bovine lactoferrin, as adjuvant therapy to metronidazole in women with recurrent BV. 30525953 2019
CUI: C0085166
Disease: Bacterial Vaginosis
Bacterial Vaginosis
0.020 Biomarker disease BEFREE We report here the antimicrobial activities of two commercially existing Lactobacillus strains, Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus GLA-14 strains and their combination (Respecta® probiotic blend) against four different pathogens responsible for both bacterial vaginosis ( Gardenerella vaginalis and Atopobium vaginae) and aerobic vaginitis ( Staphylococcus aureus and Escherichia coli) by co-culturing assay. 28580872 2017