DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Disease: Autistic Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 Biomarker disease BEFREE Disrupted in Schizophrenia 1 (DISC1) is a key susceptibility gene implicated in major mental illnesses, such as schizophrenia, depression, bipolar disorder and autism, but the link between this protein and the pathology of these diseases remains unclear. 22291444 2012
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 Biomarker disease BEFREE Disrupted in schizophrenia 1 (DISC1) is a leading candidate susceptibility gene for schizophrenia, bipolar disorder and recurrent major depression, which has been implicated in other psychiatric illnesses of neurodevelopmental origin, including autism. 22434823 2012
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 Biomarker disease BEFREE Disrupted in schizophrenia 1 (DISC1) is one of the strongest supported risk genes for psychiatric disorders, such as schizophrenia, major depression, bipolar disorder, and autism. 21757008 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 GeneticVariation disease BEFREE We genotyped seven tag single nucleotide polymorphisms (SNPs) in DISC1, spanning 338 kb, in 367 autism trios (singleton and their biological parents) including 1,101 individuals. 21569632 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 GeneticVariation disease BEFREE DISC1 duplication in two brothers with autism and mild mental retardation. 20002455 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 Biomarker disease CTD_human The duplication contains seven genes including the DISC1 gene, an interesting candidate gene that has been associated to schizophrenia, bipolar disorder, autism and Asperger syndrome. 20002455 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 GeneticVariation disease BEFREE Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original translocation family, true causal variants have yet to be confirmed. 18317464 2009
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 Biomarker disease LHGDN We established association between autism and a DISC1 intragenic microsatellite (D1S2709; P=0.004). 17579608 2008
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 Biomarker disease BEFREE We established association between autism and a DISC1 intragenic microsatellite (D1S2709; P=0.004). 17579608 2008
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 Biomarker disease BEFREE Disrupted-in-schizophrenia-1 (DISC1) is one of major susceptibility factors for a wide range of mental illnesses, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions. 18762802 2008
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.380 Biomarker disease CTD_human We established association between autism and a DISC1 intragenic microsatellite (D1S2709; P=0.004). 17579608 2008