|
Bipolar Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significant down-regulation of DISC1 and up-regulation of DISC2 were observed in BD cases compared with controls.
|
30599263 |
2019 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Disrupted-in-schizophrenia 1 (<i>DISC1</i>) is a strong candidate susceptibility gene for a spectrum of neuropsychiatric diseases including schizophrenia, bipolar disorder and major depression, all of which are thought to result from interactions between gene mutations and environmental risk factors such as influenza, trauma and stress.
|
30116177 |
2018 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously described altered subcellular distribution of DISC1 and an aberrant microtubule organization in olfactory neuronal precursors (ONP) obtained from schizophrenia (SCZ) and bipolar disorder (BD) patients.
|
28927861 |
2018 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia.
|
30597994 |
2018 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We measured cortical thickness, cortical surface area, subcortical volumes, and regional cerebral blood flow (rCBF) in healthy controls (HC) (n = 24), patients diagnosed with SCZ (n = 24), patients diagnosed with bipolar disorder (BP) (n = 19), and members of the original Scottish family (n = 30) who were either carriers (T+) or noncarriers (T-) of the DISC1 translocation.
|
26301809 |
2015 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We measured cortical thickness, cortical surface area, subcortical volumes, and regional cerebral blood flow (rCBF) in healthy controls (HC) (n = 24), patients diagnosed with SCZ (n = 24), patients diagnosed with bipolar disorder (BP) (n = 19), and members of the original Scottish family (n = 30) who were either carriers (T+) or noncarriers (T-) of the DISC1 translocation.
|
26301809 |
2015 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Disrupted in schizophrenia 1 (DISC1) is a risk factor for a spectrum of neuropsychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder.
|
25272038 |
2014 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
DISC1 imaging genetics studies in healthy controls, schizophrenia, and bipolar disorder cases have revealed morphological changes in brain regions involved in the pathophysiology of psychiatric disease including the hippocampus, anterior cingulate cortex (ACC), and the striatum.
|
25012417 |
2014 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression.
|
25487992 |
2014 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Disrupted-In-Schizophrenia 1 (DISC1) is a candidate risk factor for schizophrenia, bipolar disorder and severe recurrent depression.
|
24092329 |
2014 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the role of variation in DISC1 polymorphisms on the P300 endophenotype in a large sample of patients with schizophrenia or psychotic bipolar disorder (n = 149), their unaffected relatives (n = 130), and unrelated healthy controls (n = 208) using linear regression and haplotype analysis.
|
21878470 |
2013 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, subsequent studies have shown association of DISC1 variants with a range of different neurocognitive phenotypes and psychiatric disorders, including bipolar disorder (BPD), and major depression.
|
23389941 |
2013 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Disrupted in schizophrenia 1 (DISC1) is a leading candidate susceptibility gene for schizophrenia, bipolar disorder and recurrent major depression, which has been implicated in other psychiatric illnesses of neurodevelopmental origin, including autism.
|
22434823 |
2012 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We sought to examine the effects of the DISC1 Leu(607) Phe polymorphism on brain activation in young healthy individuals at familial risk of bipolar disorder (n = 84), in a group of controls (n = 78), and in a group at familial risk of schizophrenia (n = 47), performing a language task.
|
22337479 |
2012 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Binary logistic regression revealed a nominal association for rs821616 in DISC1 for BPAD and also combined cases of BPAD or SCZ, but after correcting for multiple testing, these results were non-significant.
|
22673686 |
2012 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia.
|
21376542 |
2011 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In contrast to its effect in healthy subjects, variation in DISC1 Cys704Ser704 genotype was not associated with altered prefrontal activation in patients with schizophrenia or bipolar disorder.
|
21091867 |
2011 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This finding provides evidence supporting the role of DISC1 gene in bipolar disorder, and shows the presence of population heterogeneity.
|
21222298 |
2011 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD).
|
19255581 |
2010 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we report a harmonized association study for DISC1 in European cohorts of schizophrenia and bipolar disorder.
|
18317464 |
2009 |
|
Bipolar Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder.
|
19191256 |
2009 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Disrupted in Schizophrenia 1 (DISC1) is currently one of the most interesting candidate genes for major mental illness, having been demonstrated to associate with schizophrenia, bipolar disorder, major depression, autism, and Asperger's syndrome.
|
19251251 |
2009 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder.
|
19300510 |
2009 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest novel candidates and 1 gene (DISC1) previously associated with schizophrenia that merit further study in bipolar disorder.
|
18180429 |
2008 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Disrupted-in-schizophrenia-1 (DISC1) is one of major susceptibility factors for a wide range of mental illnesses, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions.
|
18762802 |
2008 |