DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Disease: Pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain 		0.310 GeneticVariation phenotype BEFREE NRG1×DISC1 mutant mice were generated and adult mice from each genotype were assessed for pain sensitivity (hot plate and tail flick tests), anxiety (light-dark box), and stress-induced hypothermia. 27916686 2017
CUI: C0030193
Disease: Pain
Pain 		0.310 Biomarker phenotype CTD_human At baseline, deletion of NRG1 and DISC1 each reduced thermal pain sensitivity, while deletion of COMT increased pain sensitivity. 20561508 2010