DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Disease: Anhedonia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178417
Disease: Anhedonia
Anhedonia 		0.310 AlteredExpression disease BEFREE Importantly, exogenous expression of a modified DISC1, which binds to PDE4 but not mutant HTT, normalized PDE4 activity and ameliorated anhedonia in the R6/2 mice. 28263187 2017
CUI: C0178417
Disease: Anhedonia
Anhedonia 		0.310 Biomarker disease PSYGENET Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. 17675407 2007