DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome
0.360 GeneticVariation disease BEFREE In a previous study, a Finnish group demonstrated that DISC1 polymorphisms were associated with autism and Asperger syndrome. 21569632 2011
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome
0.360 GeneticVariation disease BEFREE The Disrupted in Schizophrenia 1 (DISC1) gene has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism, and Asperger syndrome in different populations. 21222298 2011
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome
0.360 GeneticVariation disease BEFREE The duplication contains seven genes including the DISC1 gene, an interesting candidate gene that has been associated to schizophrenia, bipolar disorder, autism and Asperger syndrome. 20002455 2010
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome
0.360 Biomarker disease BEFREE Disrupted in Schizophrenia 1 (DISC1) is currently one of the most interesting candidate genes for major mental illness, having been demonstrated to associate with schizophrenia, bipolar disorder, major depression, autism, and Asperger's syndrome. 19251251 2009
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome
0.360 GeneticVariation disease BEFREE Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original translocation family, true causal variants have yet to be confirmed. 18317464 2009
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome
0.360 Biomarker disease LHGDN In addition, evidence for association to Asperger syndrome was observed with an intragenic single nucleotide polymorphism (SNP) of DISC1 (rs1322784; P=0.0058), as well as with a three-SNP haplotype (P=0.0013) overlapping the HEP3 haplotype, that was previously observed to associate with schizophrenia in Finnish families. 17579608 2008
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome
0.360 GeneticVariation disease BEFREE Here we have addressed the allelic diversity of the DISC1, DISC2 and TRAX genes, clustered in 1q42, in Finnish families ascertained for infantile autism (97 families, n(affected)=138) and Asperger syndrome (29 families, n(affected)=143). 17579608 2008
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome
0.360 Biomarker disease CTD_human In addition, evidence for association to Asperger syndrome was observed with an intragenic single nucleotide polymorphism (SNP) of DISC1 (rs1322784; P=0.0058), as well as with a three-SNP haplotype (P=0.0013) overlapping the HEP3 haplotype, that was previously observed to associate with schizophrenia in Finnish families. 17579608 2008