Unipolar Depression
|
0.800 |
Biomarker
|
disease |
CTD_human |
DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders.
|
29643356 |
2018 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
A balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia.
|
30597994 |
2018 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Disrupted-in-schizophrenia 1 (<i>DISC1</i>) is a strong candidate susceptibility gene for a spectrum of neuropsychiatric diseases including schizophrenia, bipolar disorder and major depression, all of which are thought to result from interactions between gene mutations and environmental risk factors such as influenza, trauma and stress.
|
30116177 |
2018 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression.
|
29467617 |
2018 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.
|
25705664 |
2015 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Recently several potential susceptibility genes for major psychiatric disorders (schizophrenia and major depression) such as disrupted-in-schizophrenia 1(DISC1), dysbindin and pituitary adenylate cyclase-activating polypeptide (PACAP) have been reported.
|
25595671 |
2015 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions.
|
24934694 |
2014 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy.
|
25043320 |
2014 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Disrupted in schizophrenia 1 (DISC1) is a risk factor for a spectrum of neuropsychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder.
|
25272038 |
2014 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions.
|
24934694 |
2014 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
No evidence of DISC1-associated morphological changes in the hippocampus, anterior cingulate cortex, or striatum in major depressive disorder cases and healthy controls.
|
25012417 |
2014 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy.
|
25043320 |
2014 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression.
|
25487992 |
2014 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
However, subsequent studies have shown association of DISC1 variants with a range of different neurocognitive phenotypes and psychiatric disorders, including bipolar disorder (BPD), and major depression.
|
23389941 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Disrupted in schizophrenia 1 (DISC1) is one of the strongest supported risk genes for psychiatric disorders, such as schizophrenia, major depression, bipolar disorder, and autism.
|
21757008 |
2011 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The Disrupted in Schizophrenia 1 (DISC1) gene has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism, and Asperger syndrome in different populations.
|
21222298 |
2011 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Disrupted in Schizophrenia 1 (DISC1) is currently one of the most interesting candidate genes for major mental illness, having been demonstrated to associate with schizophrenia, bipolar disorder, major depression, autism, and Asperger's syndrome.
|
19251251 |
2009 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Recently, PDE4A5 has been shown to bind with disrupted in schizophrenia 1 (DISC1), which has been identified as a risk factor for schizophrenia, bipolar disorder, and major depression.
|
19018233 |
2008 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Disrupted-in-schizophrenia-1 (DISC1) is one of major susceptibility factors for a wide range of mental illnesses, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions.
|
18762802 |
2008 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In a large Scottish pedigree, a balanced translocation t(1;11) (q42.1;q14.3) disrupting the DISC1 and DISC2 genes segregates with major mental illness, including schizophrenia and unipolar depression.
|
18164685 |
2008 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
MGD |
Behavioral phenotypes of Disc1 missense mutations in mice.
|
17481393 |
2007 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Since then, genetic analysis has implicated DISC1 in schizophrenia, schizoaffective disorder, bipolar affective disorder, and major depression.
|
16699061 |
2006 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.
|
16959794 |
2006 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we used heterozygous Disc1 mutant (Het) mice to evaluate the DISC1 haploinsufficiency model of schizophrenia.
|
31721208 |
2020 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the DISC1 gene mutation is linked to schizophrenia and depression.
|
31601402 |
2019 |