IL17B, interleukin 17B, 27190

N. diseases: 116; N. variants: 2
Disease: Arthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE Although mAbs against IL-19 and IL-20 have each been shown to modulate disease severity of collagen-induced arthritis in animal models, and anti-IL-20 therapeutic Ab has exhibited some efficacy in the treatment of RA in clinical trials, benefits for a complete blockade of these functionally redundant cytokines remain to be explored. 27619991 2016
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE In experimental models, anti-IL-20 monoclonal antibody ameliorates arthritis severity, protects against ovariectomized-induced bone loss, and inhibits breast tumor-induced osteolysis. 24816455 2014
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE In vivo, adoptive transfer of IL-17B- and IL-17C-transduced CD4(+) T cells evidently exacerbated arthritis. 17982105 2007
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE Thus, IL-20 may modulate the incidence and severity of arthritis and play important roles at local sites of inflammation. 16947773 2006