GNMT, glycine N-methyltransferase, 27232

N. diseases: 57; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 Biomarker group BEFREE The metabolic physiology that sustains liver tumor formation in GNMT-null mice is unknown. 30850319 2019
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 Biomarker group BEFREE GNMT serves multiple roles which include a methyl group transfer enzyme and a liver tumor suppressor. 30987732 2019
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 AlteredExpression group BEFREE Injection of AAV serotype 8 (AAV8) vector carrying the GNMT gene (AAV8-GNMT) in Gnmt<sup>-/-</sup> mice increased GNMT expression and downregulated pro-inflammatory responses, resulting in reduced liver damage and incidence of liver tumors. 30217986 2018
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 Biomarker group BEFREE Glycine N-methyltransferase (GNMT) is a folate binding protein commonly diminished in human hepatoma yet its role in tumor development remains to be established. 23922098 2014
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 Biomarker group CTD_human Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver. 21137059 2010
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 Biomarker group MGD Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility. 19035462 2009
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 Biomarker group LHGDN Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility. 19035462 2009
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 Biomarker group MGD Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. 17937387 2007