SGSM3, small G protein signaling modulator 3, 27352

N. diseases: 259; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0595921
Disease: Intraocular pressure disorder
Intraocular pressure disorder 		0.020 AlteredExpression disease BEFREE <b>Abbreviations</b>: POAG = primary open-angle glaucoma; RGC = retinal ganglion cell; OCTA = optical coherence tomography angiography; RNFL = retinal nerve fiber layer; PPG = pre-perimetric primary open-angle glaucoma; EG = early perimetric primary open-angle glaucoma; IOP = intraocular pressure; PSD = pattern standard deviation; MD = mean deviation; GCC = ganglion cell complex; SBP = systolic blood pressure; DBP = diastolic blood pressure; MAP = mean arterial pressure; MOPP = mean ocular perfusion pressure; wiVD = whole image vessel density; ParaVD = parafoveal vessel density; PeriVD = perifoveal vessel density; RPC VD = radial peripapillary capillary vessel density; AUC = area under the receiver operating curve. 31587582 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE <i>FAM83D</i>, a microtubule-associated protein (MAP), is overexpressed in diverse types of human cancer. 29088801 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE <i>FAM83D</i>, a microtubule-associated protein (MAP), is overexpressed in diverse types of human cancer. 29088801 2017
CUI: C1739135
Disease: Progression of prostate cancer
Progression of prostate cancer 		0.010 AlteredExpression disease BEFREE Progression of prostate cancer to a fatal androgen-independent disease is associated with activation of MAP kinase, consistent with chronic stimulation of the Ras-signaling pathway. 17918750 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 Biomarker disease BEFREE Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a specific type of slow and progressive neurodegeneration, which involves the abnormal hyperphosphorylation of the microtubule associated protein (MAP) tau. 19184068 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Tumors that were intrinsically sensitive or resistant to doxorubicin or docetaxel evoked distinct gene expression changes in response to the drug; doxorubicin-resistant tumors upregulated genes that were enriched for ErbB signaling, ubiquitin-mediated proteolysis, TGF-beta signaling, and MAP-kinase signaling pathways, whereas docetaxel-resistant tumors upregulated genes that were enriched for focal adhesion and regulation of actin cytoskeleton. 19352302 2009
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia 		0.010 GeneticVariation disease BEFREE Juvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/myeloproliferative disorder of early childhood characterized by mutations of the RAS-RAF-MAP kinase signaling pathway. 22183880 2012
CUI: C0678329
Disease: drug substitution (abuse)
drug substitution (abuse) 		0.010 GeneticVariation disease BEFREE Drug substitution experiments using the NSAIDs celecoxib and ibuprofen or the MAP-ERK kinase inhibitor PD325901 and the RAF inhibitor RAF265 suggest that inhibition of COX and mitogen-activated protein kinase signaling are targets for the synergistic cytotoxicity of sorafenib and diclofenac. 22962324 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.030 Biomarker group BEFREE Stroke severity was associated with ΔMAP (B coefficient -.46, p-value .011). 29777579 2018
CUI: C0020625
Disease: Hyponatremia
Hyponatremia 		0.010 Biomarker phenotype BEFREE Hyponatremia and MAP-kinase inhibitors in malignant melanoma: Frequency, pathophysiological aspects and clinical consequences. 30387922 2019
CUI: C0085136
Disease: Central Nervous System Neoplasms
Central Nervous System Neoplasms 		0.010 AlteredExpression group BEFREE MAP-2e was not expressed in non-CNS tumors or neuroblastomas.Thus. neuroectodermal tumors that have glial characteristics express this developmental marker of immature glia. 12025943 2002
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.060 AlteredExpression disease BEFREE MAP-2e was not expressed in non-CNS tumors or neuroblastomas.Thus. neuroectodermal tumors that have glial characteristics express this developmental marker of immature glia. 12025943 2002
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE MAP-2e immunostaining also delineated tumor invasion into adjacent gray and white matter, indicating that MAP-2e appears to be a useful marker for examining the infiltration of malignant cells into surrounding tissue. 12025943 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. 12037682 2002
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. 17406030 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE MAP kinase signalling pathways in cancer. 17496922 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE MAP kinase signalling pathways in cancer. 17496922 2007
CUI: C0751690
Disease: Malignant Peripheral Nerve Sheath Tumor
Malignant Peripheral Nerve Sheath Tumor 		0.010 Biomarker disease BEFREE MAP kinase pathways (ERK1,2 and JNK) were further examined in ST88-14, a neurofibromin-deficient MPNST cell line. 20680410 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.030 Biomarker disease BEFREE MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. 21406405 2011
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 Biomarker disease BEFREE MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. 21406405 2011
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.030 Biomarker disease BEFREE MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. 21406405 2011
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.030 Biomarker disease BEFREE MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. 21406405 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE MAP kinase signaling and inhibition in melanoma. 22945644 2013
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.010 GeneticVariation disease BEFREE MAP kinase genes and colon and rectal cancer. 23027623 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE MAP kinase signaling proteins have major implications in the molecular oncogenesis of breast cancers and have been extensively investigated as putative targets for therapy. 23900300 2013