|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Downregulation of Sam68 impacts the growth and survival of human tumor keratinocytes and genetic ablation of Sam68 delays the onset of basal cell carcinomas (BCC) in Gli2-transgenic mice.
|
31436046 |
2019 |
|
Carcinoma, Basal Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lastly, we found prominent nuclear activity of GLI2, YAP and β-catenin, concomitant with increased ROCK signalling and stromal fibrosis in human BCC.
|
28820907 |
2017 |
|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
The transcription factors GLI1 and GLI2 have been implicated in both the initiation and progression of several cancers, including basal cell carcinoma.
|
23792444 |
2014 |
|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
The staining for Gli2 in the BCC group was completely negative, but indicated the presence of Gli2 in the control patients (1.15 Gli2+ cells/100 cells).
|
24203628 |
2013 |
|
Carcinoma, Basal Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GLI2 (GLI-Kruppel family member 2), a zinc finger transcription factor that mediates Hedgehog signaling, is implicated in the progression of an ever-growing number of human malignancies, including prostate and pancreatic cancer, as well as basal cell carcinoma of the skin.
|
19797115 |
2009 |
|
Carcinoma, Basal Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Primary human keratinocytes retrovirally expressing GLI1(-) and GLI2(-) showed elevated levels of beta-tubulin III and ARC but not Neurofilament or GAP-43, suggesting that beta-tubulin III and Arc may be early targets of aberrant Gli expression in BCC, whereas expression of Neurofilament and GAP-43 are either later, downstream targets or under control of alternative pathways.
|
19479712 |
2009 |
|
Carcinoma, Basal Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results reveal a key role of GLI2 in activation of the activin/BMP antagonist FST in response to HH signaling and provide new evidence for a regulatory interaction between HH and activin/BMP signaling in hair follicle development and BCC.
|
18319260 |
2008 |
|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
In order to examine the function of alpha v beta 6, we transfected the transcription factors Gli1 or Gli2 into NTERT, human keratinocytes to generate a BCC model.
|
18451156 |
2008 |
|
Carcinoma, Basal Cell
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
We could now demonstrate that Gli2 gene silencing in BCC tissues made the tumor sensitive to TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated cell death by downregulating cFlip.
|
18264131 |
2008 |
|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is indication in the literature that preventing Gli2 function may inhibit BCC formation and growth in vivo; however, the mechanism is unclear and difficult to study in humans.
|
17721996 |
2008 |
|
Carcinoma, Basal Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma.
|
15140221 |
2004 |
|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
The zinc-finger transcription factor Gli2 has been identified as critical mediator of the Hh signal at the distal end of the pathway, but the molecular mechanisms by which Gli2 regulates cell proliferation or induces epidermal malignancies such as basal cell carcinoma are still unclear.
|
14691458 |
2004 |
|
Carcinoma, Basal Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, using in situ hybridization, we show that GLI2 is expressed in the interfollicular epidermis and the outer root sheath of hair follicles in normal skin as well as in BCC tumor islands.
|
15175043 |
2004 |
|
Carcinoma, Basal Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Of four spliced Gli2 isoforms designated Gli2alpha, beta, gamma and delta, the expression of Gli2beta mRNA was increased the most in BCCs.
|
12786818 |
2003 |
|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
In striking contrast, K5-Gli2 mice overexpressing wild-type Gli2 developed only BCCs.
|
12235001 |
2002 |
|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma.
|
12165851 |
2002 |
|
Carcinoma, Basal Cell
|
0.400 |
Biomarker
|
disease |
CTD_human |
Basal cell carcinomas in mice overexpressing Gli2 in skin.
|
10700170 |
2000 |