|
Obesity
|
0.220 |
Biomarker
|
disease |
BEFREE |
Here we report that normal diet-fed Glrx-deficient mice (Glrx<sup>-/-</sup>) spontaneously develop obesity, hyperlipidemia, and hepatic steatosis by 8 months of age.
|
27958883 |
2017 |
|
Obesity
|
0.220 |
AlteredExpression
|
disease |
BEFREE |
We have observed distinct differences in the expression levels of Grx in pancreatic islets between obese, diabetic db mice and lean, non-diabetic controls.
|
28542222 |
2017 |
|
Parkinson Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Increased GLRX copy number in PD patients was associated with earlier PD onset, and Grx1 levels correlated with levels of proinflammatory tumor necrosis factor-alpha (TNF-α) in mouse and human brain samples, prompting mechanistic in vitro studies.
|
27224303 |
2016 |
|
Parkinson Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We subsequently investigated the potential role of Grx1 deficiency in PD pathogenesis by examining the consequences of loss of the Caenorhabditis elegans Grx1 homolog in well-established worm models of familial PD caused by overexpression of pathogenic human LRRK2 mutants G2019S or R1441C.
|
25355420 |
2015 |
|
Parkinson Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Glutaredoxin 1 protects dopaminergic cells by increased protein glutathionylation in experimental Parkinson's disease.
|
22816731 |
2012 |
|
Parkinson Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Increased GLRX copy number in PD patients was associated with earlier PD onset; and Grx1 levels correlated with levels of proinflammatory tumor necrosis factor-α in mouse and human brain samples.
|
29183158 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In our previous study, IL-1β was found to be one of the key node genes during oral malignant transformation, and glutaredoxin 1 (Grx1) was identified as one of the downstream genes of IL-1β in tumor microenvironment.
|
27658048 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Mouse tumor xenografts were used to assess the effect of GLRX in vivo.
|
30661098 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The contents of reduced glutathione and thioltransferase activity were significantly increased in tumor compared to non-tumor tissue.
|
28288548 |
2017 |
|
Diabetes
|
0.020 |
Biomarker
|
disease |
BEFREE |
Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various disease contexts, including diabetes.
|
27224303 |
2016 |
|
Diabetes
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, 61 bacterial gene clusters discriminated early and later stages of diabetes with elevations of enzymes related to stress response (e.g., glutathione and glutaredoxin) and amino acid, carbohydrate, and bacterial cell wall metabolism.
|
30016149 |
2018 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, 61 bacterial gene clusters discriminated early and later stages of diabetes with elevations of enzymes related to stress response (e.g., glutathione and glutaredoxin) and amino acid, carbohydrate, and bacterial cell wall metabolism.
|
30016149 |
2018 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various disease contexts, including diabetes.
|
27224303 |
2016 |
|
Myeloid Leukemia, Chronic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, by using pharmacological inhibitors, scavengers and molecular approaches, we identified that enhanced ROS generation via NOX2 and mitochondria, reduced Grx1/2 expression and GSH level associated with NFκB S-glutathionylation in PMNs from CML patients.
|
27264783 |
2016 |
|
Myeloid Leukemia, Chronic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that sustained activation of STAT5 induced by Bcr-Abl in chronic myeloid leukemia (CML) cells promotes ROS production by repressing expression of two antioxidant enzymes, catalase and glutaredoxin-1(Glrx1).
|
27566554 |
2017 |
|
Lung diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Decreased expression of Grx1 further suggests the impairment of this system both in inflammatory and fibrotic lung diseases, consistent with the down-regulation of Grx1 by TGF-beta in vitro.
|
15297967 |
2004 |
|
Lung diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases.
|
31693398 |
2020 |
|
Pulmonary Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Meanwhile, exogenous Glrx administration can reverse pathological lung fibrosis.
|
31813265 |
2020 |
|
Pulmonary Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings suggest the therapeutic potential of exogenous GLRX in treating lung fibrosis.
|
29988126 |
2018 |
|
Conotruncal defect
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The risk of CTHD among children who inherited a paternally derived copy of the A allele on GLRX (rs17085159) or the T allele of GLRX (rs12109442) was 0.23 (95%CI: 0.12, 0.42; p = 1.09 × 10<sup>-6</sup> ) and 0.27 (95%CI: 0.14, 0.50; p = 2.06 × 10<sup>-5</sup> ) times the risk among children who inherited a maternal copy of the same allele.
|
29399948 |
2018 |
|
Conotruncal defect
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
One SNP pair (i.e., rs4764267 and rs6556883) located in gene MGST1 and GLRX, respectively, was found to be associated with CTD risk after multiple testing adjustment using simpleM, a modified Bonferroni correction approach (nominal p-value of 4.62e-06; adjusted p-value of .04).
|
31851787 |
2020 |
|
Limb ischemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
After hind limb ischemia surgery Glrx TG mice demonstrated impaired blood flow recovery, associated with lower capillary density and poorer limb motor function compared with wild type littermates.
|
24482236 |
2014 |
|
Limb ischemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we examined the role of EC-specific Glrx up-regulation in distinct models of angiogenesis; namely, hind limb ischemia and tumor angiogenesis.
|
31647879 |
2019 |
|
Anaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The blockage of PI-3K/Akt or p38 kinase with SB203580 and LY294002 accelerated PEP-1-GRX-1-induced dedifferentiation, but did not have any effect on PEP-GRX-1-induced ER stress.
|
29366902 |
2018 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that Grx1 induction plays a key role in mediating the protective effect of laminar blood flow and suggest that Grx1 may be a potential therapeutic target for atherosclerosis.
|
29138498 |
2017 |