|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In our study, there was a significant association between the C825T polymorphism of the GNB3 gene and the occurrence of hypertension (odds ratio 1.275; 95% confidence interval 1.042-1.559; p=0.018) in the dominant model, after multivariate analysis.
|
29853161 |
2018 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, GNB3 genotypes could be associated with clinical worsening in pulmonary hypertension (PH) treated with PDE-5I.
|
26821322 |
2016 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Polymorphisms in Gβ3 (GNB3) are associated with many human disorders (e.g. hypertension, diabetes and obesity) but the role of GNB3 in these pathogeneses remains unclear.
|
25093805 |
2014 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that the previous cumulative evidence does not support the proposal that haplotypes formed by common GNB3 polymorphisms might contribute either to the development of hypertension and obesity, or to the variation in the SBP, DBP and BMI.
|
24477587 |
2014 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The TT genotype of the C825T GNB3 gene polymorphism was found to be a significant risk factor for the incidence of CVD and stroke independent of hypertension and other established CVD risk factors in a Japanese population.
|
23595158 |
2013 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Angiotensinogen (AGT), G-protein β3-subunit (GNB3) and cytochrome P450 3A5 (CYP3A5) are candidate hypertension susceptibility genes and risk alleles at these loci have been thought to arise owing to human adaptation to climatic changes following the migration out-of-Africa.
|
23324949 |
2013 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C825T polymorphism of the G-protein β3 subunit gene and its association with hypertension and stroke: an updated meta-analysis.
|
23799054 |
2013 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We assessed whether distributions of 3 single nucleotide polymorphisms in genes coding for components of G protein signaling pathways that have been associated with hypertension differ between women with preeclampsia and normotensive pregnant women; the G protein β3 subunit gene (GNB3) C825T polymorphism (rs5443), the angiotensin II type 1 receptor gene (AGTR1) 3'UTR A1166C polymorphism (rs5186), and the regulator of G protein signaling 2 gene (RGS2) 3'UTR C1114G polymorphism (rs4606).
|
23339167 |
2013 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Interactions between genetic variants of FTO and GNB3 influence clinical parameters to augment hypertension.
|
23691120 |
2013 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In summary, this study identified one novel SNP in GNB3 and one novel SNP in INSR that are strongly associated with young-onset hypertension.
|
22534794 |
2012 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression.
|
21709600 |
2011 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese.
|
21364877 |
2011 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The G-protein β 3(GNB3) C825T polymorphism has been linked with hypertension, salt sensitivity and multiple diseases.
|
21198262 |
2010 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
No association was found between the C285T polymorphism of the GNB3 and hypertension.
|
20539277 |
2010 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The further adjustment for hypertension abolished the association between the GNB3 C825T variant and DPN (OR = 1.95, p = 0.18).
|
19597293 |
2009 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Furthermore, a latitudinal cline was identified both for the allele frequencies of the SNPs associated with hypertension (CYP3A5, AGT, GNB3), as well as for those associated with the ability to taste phenylthiocarbamide (TAS2R38).
|
18248681 |
2008 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The 825T allele of the GNB3 gene is implicated in adipose distribution, predisposing to obesity and hypertension.
|
18192837 |
2008 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
LHGDN |
G protein beta3 subunit gene polymorphism in Turkish hypertensives.
|
18849222 |
2008 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.
|
17299380 |
2007 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thus, we investigated how genetic variation in the GNB3 gene is associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, and diabetic therapies in 427 Japanese subjects with type 2 diabetes mellitus and in 368 Japanese subjects who underwent general health examinations.
|
17161225 |
2007 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Genetics and hypertension.
|
17341998 |
2007 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The polymorphism C825T of the gene encoding the G-protein beta 3-subunit (GNB3) was found to be associated with an increased prevalence of hypertension in a number of studies.
|
16487269 |
2006 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
LHGDN |
Lack of association between the C825T polymorphism in G-protein beta-3 subunit and arterial blood pressure levels in cardiovascular disease free individuals: the ATTICA epidemiological study.
|
16424860 |
2006 |