Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present meta-analysis indicated the GNB3 C825T polymorphism is related to increased EH exclusively in Caucasians.
|
28540932 |
2017 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death.
|
28067546 |
2017 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The GNB3 splice variant rs5443" genes_norm="2784">C825T (rs5443) is associated with risk for essential hypertension (EH) and efficacy of therapeutic drugs targeting GPCRs.
|
26712426 |
2016 |
Essential Hypertension
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate the potential use of a GNB3-specific antisense morpholino, as a pharmacogenetic therapy for essential hypertension.
|
27028457 |
2016 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, a significant association was found between GNB3 C825T polymorphism and risk of EH when all studies were pooled with a random-effects model for T versus C (OR=1.09, 95% CI: 1.04-1.19).
|
24346074 |
2013 |
Essential Hypertension
|
0.400 |
Biomarker
|
disease |
BEFREE |
The genes FTO and GNB3 are implicated in essential hypertension but their interaction remains to be explored.
|
23691120 |
2013 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was no significant association identified between GNB3-C825T polymorphism and EH in Han Chinese population.
|
22714918 |
2012 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The role of G protein β3 subunit polymorphisms C825T, C1429T, and G5177A in Turkish subjects with essential hypertension.
|
21473734 |
2011 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Data from the present study suggest that the T825 variant of the G protein beta 3 subunit gene is unlikely to constitute major susceptibility loci for essential hypertension in Caucasian RA patients.
|
19811352 |
2009 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Case-control association analysis showed a significant association between EH and both the ALDH2 (Lys487Glu) and GNB3 (C825T) variants.
|
17785925 |
2007 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls.
|
17278960 |
2007 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis indicated that the GNB3 825T allele carriers were positively associated with EH in males (odds ratio (OR) for TT/CT, 1.459; 95% confidence interval (CI), 1.048-2.033, P=0.0255).
|
17066084 |
2007 |
Essential Hypertension
|
0.400 |
Biomarker
|
disease |
BEFREE |
Is the genetic variability of GNB3 a causative factor underlying the pathogenesis of essential hypertension?
|
16600156 |
2006 |
Essential Hypertension
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine whether four potential genetic factors (polymorphisms in genes for alpha-adducin, beta-adducin, the G-protein beta-3 subunit and nitric oxide synthase) are important for the development of essential hypertension (EH) in Slovenian children and young adults with EH.
|
16497648 |
2006 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GNB3 C825T and ACE I/D polymorphisms on the sodium-proton exchanger and the prevalence of essential hypertension in males.
|
16314202 |
2006 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
G protein beta 3 subunit gene variants and essential hypertension in the northern Chinese Han population.
|
15996174 |
2005 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GNB3 825 C>T is likely to be a significant risk factor for LVH but not for EH in the Emirati population, thereby strengthening the view that LVH is genetically a separate clinical entity.
|
15614196 |
2005 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension.
|
15200440 |
2004 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the polymorphisms in the GNB3 gene and ACE gene, solely or combined, did not confer a significantly increased risk for the development of EH in the Kazakh isolate of northeast China.
|
15042113 |
2004 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Renin-angiotensin-aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertension.
|
12624609 |
2003 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity.
|
12730030 |
2003 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The G-protein beta3 subunit (GNB3) C825T polymorphism was detected through a classical candidate gene approach using cell lines with enhanced G-protein activation from patients with essential hypertension.
|
12530935 |
2003 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T allele of the GNB3 gene has been associated with essential hypertension and obesity in cross-sectional studies.
|
14557282 |
2003 |
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to determine if there is an association of G-protein b3 subunit (GNB3) gene polymorphisms and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in a St. Petersburg population.
|
12011775 |
2002 |