GNB3, G protein subunit beta 3, 2784

N. diseases: 192; N. variants: 10
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD. 28225778 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE Our findings provide empirical evidence that GNB3 C825T polymorphisms may be correlated with the efficacy of antidepressants in the treatment of MDD, especially among Asians patients. 25451402 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE Genetic variation in the G-protein β3 subunit (GNB3) has previously been associated with gene splicing that has been further linked to increased signal transduction and major depressive disorder. 24882179 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET Genetic variation in the G-protein β3 subunit (GNB3) has previously been associated with gene splicing that has been further linked to increased signal transduction and major depressive disorder. 24882179 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression. 22222462 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression. 22222462 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET We here report analysis of data from GENDEP, a part-randomized pharmacogenomic trial, on the outcome of 811 subjects with major depression undergoing treatment with either escitalopram or nortriptyline in which the C825T SNP and three further SNPs in GNB3 were genotyped. 20826553 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression. 18325652 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression. 18325652 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to mirtazapine in Korean patients with MDD. 17943025 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 Biomarker disease PSYGENET Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to mirtazapine in Korean patients with MDD. 17943025 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE In female subjects, T-allele of GNB3 polymorphism increases the risk of being a treatment-resistant patient with MDD. 17066254 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.380 GeneticVariation disease BEFREE These results suggest that the T allele of the C825T polymorphism in the GNB3 gene is associated with MDD. 14647404 2004