Major Depressive Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD.
|
28225778 |
2017 |
Major Depressive Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Our findings provide empirical evidence that GNB3 C825T polymorphisms may be correlated with the efficacy of antidepressants in the treatment of MDD, especially among Asians patients.
|
25451402 |
2015 |
Major Depressive Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the G-protein β3 subunit (GNB3) has previously been associated with gene splicing that has been further linked to increased signal transduction and major depressive disorder.
|
24882179 |
2014 |
Major Depressive Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Genetic variation in the G-protein β3 subunit (GNB3) has previously been associated with gene splicing that has been further linked to increased signal transduction and major depressive disorder.
|
24882179 |
2014 |
Major Depressive Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression.
|
22222462 |
2012 |
Major Depressive Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression.
|
22222462 |
2012 |
Major Depressive Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
We here report analysis of data from GENDEP, a part-randomized pharmacogenomic trial, on the outcome of 811 subjects with major depression undergoing treatment with either escitalopram or nortriptyline in which the C825T SNP and three further SNPs in GNB3 were genotyped.
|
20826553 |
2011 |
Major Depressive Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression.
|
18325652 |
2008 |
Major Depressive Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression.
|
18325652 |
2008 |
Major Depressive Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to mirtazapine in Korean patients with MDD.
|
17943025 |
2007 |
Major Depressive Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to mirtazapine in Korean patients with MDD.
|
17943025 |
2007 |
Major Depressive Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
In female subjects, T-allele of GNB3 polymorphism increases the risk of being a treatment-resistant patient with MDD.
|
17066254 |
2007 |
Major Depressive Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the T allele of the C825T polymorphism in the GNB3 gene is associated with MDD.
|
14647404 |
2004 |