|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Coronary Heart Disease and ABO Blood Group in Diabetic Women: A Case-Control Study.
|
31092877 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
All patients were genotyped for 45 genome-wide significant CAD risk variants, including rs495828 at the ABO locus.
|
30837090 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multiple linear regression analysis was performed to test the association between the severity of CAD and ABO blood groups.
|
31645856 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetically instrumented blood lead was not associated with CAD (odds ratio (OR) 1.01 per effect size of log transformed blood lead, 95% confidence interval (CI) 0.97, 1.05), blood pressure (systolic -0.18 mmHg, 95% CI -0.44 to 0.08 and diastolic -0.03 mmHg, 95% CI -0.09 to 0.15) or diabetes (OR 0.98, 95% CI 0.92 to 1.03) using MR-PRESSO estimates corrected for an outlier SNP (rs550057) from the highly pleiotropic gene ABO.
|
31690775 |
2019 |
|
Malignant neoplasm of pancreas
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSIONS The risk for pancreatic cancer was associated with ABO blood type, DM, and chronic pancreatitis in a Chinese population.
|
30582832 |
2018 |
|
Malignant neoplasm of pancreas
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Stratified analyses of associations between E-DII quintiles and PC by genotype-derived ABO blood type did not show interaction by blood type (Pinteraction = 0.10 in PanC4 and Pinteraction=0.13 in PanScan).
|
29800239 |
2018 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Type non-O of the ABO blood group system has been associated with coronary artery disease, thrombosis, and a worse prognosis.
|
29958715 |
2018 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Malignant neoplasm of pancreas
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study demonstrates that pancreatic cancer risk is influenced by ABO status, in particular blood groups O and A<sub>1</sub> , and that this association may reflect also in tumor resectability and survival.
|
28556564 |
2017 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
ABO blood group is a risk factor for coronary artery disease in patients with poor blood pressure control.
|
28513229 |
2017 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interestingly, haplotype analysis indicated that the QAGA or H4 haplotype of ADAMTS13 gene had a protective effect on CAD after adjustment for ABO blood group [odds ratio (OR) = 0.3, 95% confidence interval (CI) = 0.1, 0.6] and major CAD risk factors (OR = 0.3, 95% CI = 0.1, 0.7).
|
27536857 |
2017 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The present study demonstrates that blood type O was independently and positively associated with an open culprit artery in patients with AMI, suggesting that the ABO blood type is not only associated with the susceptibility to coronary artery disease but also to spontaneous reperfusion in AMI patients.
|
28387531 |
2017 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
ABO blood groups have been confirmed to be associated with cardiovascular diseases such as coronary artery disease.
|
27988281 |
2017 |
|
Malignant neoplasm of pancreas
|
0.500 |
Biomarker
|
disease |
BEFREE |
Consistent with assessment using a false discovery rate approach, significant associations with ABO blood group were observed for cancer of the pancreas, breast, and upper gastrointestinal tract (mouth, salivary glands, pharynx, esophageal adenocarcinoma and stomach).
|
27459465 |
2016 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWAS) identified several single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD) and myocardial infarction (MI) locus in ABO gene.
|
27542834 |
2016 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Risk loci for ischemic stroke and its subtypes have been implicated in atrial fibrillation (PITX2 and ZFHX3), coronary artery disease (ABO, chr9p21, HDAC9, and ALDH2), blood pressure (ALDH2 and HDAC9), pericyte and smooth muscle cell development (FOXF2), coagulation (HABP2), carotid plaque formation (MMP12), and neuro-inflammation (TSPAN2).
|
27796860 |
2016 |
|
Malignant neoplasm of pancreas
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, one single nucleotide polymorphism (SNP) rs505922 in ABO gene has been implicated in susceptibility to pancreatic cancer across different populations, but different results were found in other types of cancer.
|
25656610 |
2015 |
|
Malignant neoplasm of pancreas
|
0.500 |
Biomarker
|
disease |
CTD_human |
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
|
26098869 |
2015 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
Malignant neoplasm of pancreas
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study (GWAS) and other work have shown that ABO alleles are associated with pancreatic cancer risk.
|
23816557 |
2014 |
|
Malignant neoplasm of pancreas
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The ABO variants were associated with risk of OSCC and pancreatic cancers and AFP variants with risk of hepatocellular cancer.
|
23300138 |
2014 |
|
Malignant neoplasm of pancreas
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results are compatible with the previously reported association between the ABO gene and pancreatic cancer, and show that the effect of these common variants at the ABO locus on the P-LIP and ACE levels is largely opposing and pleiotropic.
|
24586218 |
2014 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.
|
24745723 |
2014 |
|
Malignant neoplasm of pancreas
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Since glycosyltransferase activity, encoded by ABO, is higher for the A1 variant compared with the A2 variant, we investigated the hypothesis that A1 carriers were at an increased risk of pancreatic cancer.
|
23403949 |
2013 |