Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
We also identify a new exon 2b in GOLGA2 transcript and the exon exclusion contributes to PTEN knockdown-induced tumorigenesis by promoting dramatic Golgi extension and secretion, and PTEN depletion significantly sensitizes cancer cells to secretion inhibitors brefeldin A and golgicide A.
|
29921876 |
2018 |
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion.
|
28127051 |
2017 |
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Whether the loss of GM130 solely affects polarity, or whether it affects other processes relevant for tumorigenesis remains unclear.
|
25892554 |
2015 |
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, we found that GM130 upregulated expression of the key EMT regulator Snail (SNAI1), which mediated EMT activation and cell invasion by GM130.
|
26617790 |
2015 |
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In a panel of breast cancer cells lines, we investigated the consequences of GM130 depletion on traits of relevance for tumor progression, such as survival, proliferation, adhesion, migration and invasion.
|
25892554 |
2015 |
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
These findings establish a previously unrecognized role for a GM130-RasGRF-Cdc42 connection in regulating polarity and tumorigenesis.
|
25208761 |
2014 |
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, downregulation of GOLGA2/GM130 decreased angiogenesis and cancer cell invasion in vitro and suppressed tumorigenesis in lung cancer mice model.
|
22735382 |
2012 |
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, downregulation of GOLGA2/GM130 decreased angiogenesis and cancer cell invasion in vitro and suppressed tumorigenesis in lung cancer mice model.
|
22735382 |
2012 |
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GOLGA2 and hnRNPD were identified as two novels differentially expressed proteins in human CRC.
|
30927204 |
2019 |
Neuromuscular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Recently, homozygous loss of function of GOLGA2, of which previous in vitro studies suggested an essential role in maintenance of Golgi structure and in mitosis, has been associated with a neuromuscular disorder in human patients, which highlights the need for understanding the developmental roles of the golgins in vivo.
|
28509431 |
2017 |
Neuromuscular Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
GOLGA2, encoding a master regulator of golgi apparatus, is mutated in a patient with a neuromuscular disorder.
|
26742501 |
2016 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity.
|
25892554 |
2015 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Loss of GM130 abrogated cell polarity and consistent with the notion that polarity is frequently impaired in cancer, we found that GM130 is downregulated in colorectal cancer.
|
25892554 |
2015 |
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Loss of GM130 abrogated cell polarity and consistent with the notion that polarity is frequently impaired in cancer, we found that GM130 is downregulated in colorectal cancer.
|
25892554 |
2015 |
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity.
|
25892554 |
2015 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Loss of GM130 abrogated cell polarity and consistent with the notion that polarity is frequently impaired in cancer, we found that GM130 is downregulated in colorectal cancer.
|
25892554 |
2015 |
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, GM130 expression is frequently lost in colorectal and breast cancer patients.
|
25208761 |
2014 |
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, GM130 expression is frequently lost in colorectal and breast cancer patients.
|
25208761 |
2014 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, downregulation of GOLGA2/GM130 decreased angiogenesis and cancer cell invasion in vitro and suppressed tumorigenesis in lung cancer mice model.
|
22735382 |
2012 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, downregulation of GOLGA2/GM130 decreased angiogenesis and cancer cell invasion in vitro and suppressed tumorigenesis in lung cancer mice model.
|
22735382 |
2012 |
IGA Glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GM130 expression was significantly decreased in tonsil tissues and PBMC of IgAN patients; the expression of C1GALT1 decreased and Gd-IgA1 level increased significantly in patients with IgAN patients.
|
30917363 |
2019 |
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of the non-centrosomal MTOC protein GM130 reduced PCa cell proliferation and migration.
|
30816200 |
2019 |
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of the non-centrosomal MTOC protein GM130 reduced PCa cell proliferation and migration.
|
30816200 |
2019 |