GPC1, glypican 1, 2817

N. diseases: 96; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.330 AlteredExpression disease BEFREE Quantification of GPC-1 level is also pivotal to breast cancer and prostate cancer's patients. 30202003 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.330 Biomarker disease BEFREE α3(V) chains are produced in both basal-like and luminal human breast tumours, and its expression levels are tightly coupled with those of glypican-1 across breast cancer types. 28102194 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.330 AlteredExpression disease BEFREE Here we show that glypican-1 is strongly expressed in human breast cancers, whereas expression of glypican-1 is low in normal breast tissues. 11454708 2001
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.330 GeneticVariation disease UNIPROT
CUI: C0005411
Disease: Biliary Atresia
Biliary Atresia
0.320 GeneticVariation disease BEFREE Common variants of GPC1 gene were genetically involved in BA risk. 27373597 2016
CUI: C0005411
Disease: Biliary Atresia
Biliary Atresia
0.320 SusceptibilityMutation disease ORPHANET Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene. 23336978 2013
CUI: C0005411
Disease: Biliary Atresia
Biliary Atresia
0.320 GeneticVariation disease BEFREE We observed a statistically significant increase in deletions at 2q37.3 in patients with BA that resulted in deletion of one copy of GPC1, which encodes glypican 1, a heparan sulfate proteoglycan that regulates Hedgehog signaling and inflammation. 23336978 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Treatment of xenografted mice with GPC1-GEM-NPs shows a higher tumor inhibitory effect compared with controls. 31414945 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Paradoxical Role of Glypican-1 in Prostate Cancer Cell and Tumor Growth. 31391540 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE This approach is clinically relevant as a companion test to the already available diagnostic tools, since patients with GPC1-positive exosomes in peripheral blood showed decreased tumor free survival. 31400579 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.100 Biomarker disease BEFREE <b>Materials & methods:</b> This work successfully designs and evaluates GPC1-targeted, gemcitabine (GEM)-loaded multifunctional gold nanocarrier for near-infrared fluorescence (NIRF)/MRI and targeted chemotherapy against pancreatic cancer <i>in vitro</i> and <i>in vivo</i>. 31414945 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.100 Biomarker disease BEFREE Hence, enumeration of GPC1-positive EVs, solely or in conjunction with GP2, was unable to effectively distinguish between BPD and pancreatic cancer. 30800217 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.100 Biomarker disease BEFREE <b>Materials & methods:</b> This work successfully designs and evaluates GPC1-targeted, gemcitabine (GEM)-loaded multifunctional gold nanocarrier for near-infrared fluorescence (NIRF)/MRI and targeted chemotherapy against pancreatic cancer <i>in vitro</i> and <i>in vivo</i>. 31414945 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.100 Biomarker disease BEFREE Hence, enumeration of GPC1-positive EVs, solely or in conjunction with GP2, was unable to effectively distinguish between BPD and pancreatic cancer. 30800217 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE The proportion of cases by tumor type showing staining with glypican-1 and the H-score for each tumor type were evaluated. 29785020 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE However, GPC1 levels were enriched in PDAC crExos (<i>n</i> = 11), compared to the source tumors (<i>n</i> = 11; 97 ± 54 vs. 20.9 ± 12.3 pg/mL; <i>P</i> < 0.001). 29721179 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE On immunohistochemical staining, high expression levels of GPC1 were detected in about 50% of uterine cervical cancer tissues and also in a tumor that had relapsed after chemoradiotherapy. 29055044 2018
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.100 Biomarker disease BEFREE ORI-GPC1-NP is a promising theranostic platform for the simultaneous diagnosis and effective treatment of pancreatic cancer. 30425490 2018
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.100 AlteredExpression disease BEFREE GPC-1 is a type of cell surface heparan sulfate proteoglycan, which is often highly expressed in PC. 29750031 2018
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.100 Biomarker disease BEFREE Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden. 29721179 2018
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.100 Biomarker disease BEFREE Prognostic value of glypican-1 for patients with advanced pancreatic cancer following regional intra-arterial chemotherapy. 29963198 2018
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.100 Biomarker disease BEFREE Glypican-1 (GPC-1) has been recognized as biomarker of pancreatic cancer. 30202003 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.100 Biomarker disease BEFREE Prognostic value of glypican-1 for patients with advanced pancreatic cancer following regional intra-arterial chemotherapy. 29963198 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.100 Biomarker disease BEFREE ORI-GPC1-NP is a promising theranostic platform for the simultaneous diagnosis and effective treatment of pancreatic cancer. 30425490 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.100 AlteredExpression disease BEFREE GPC-1 is a type of cell surface heparan sulfate proteoglycan, which is often highly expressed in PC. 29750031 2018