ANGPT1, angiopoietin 1, 284

N. diseases: 340; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE Ang-1 has been shown to promote the development of atherosclerosis, whereas little is known about its effects on lipid metabolism and inflammation in this process. 31678621 2020
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE Infusion of Ang-(1-7), a Mas receptor (MasR) ligand, to hypercholesterolemic male mice reduced AngII-induced atherosclerosis, suggesting a protective role of the Ang-(1-7)/MasR axis. 30850299 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE Angiopoietin-1 (Ang-1) is a key regulator of angiogenesis and endothelial activation and has been studied as an objective biomarker in disease states such as atherosclerosis, sepsis, and severe malaria. 30865052 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE To test whether Ang-(1-7) modulates atherosclerosis through a NO-dependent mechanism, apoE-KO mice were treated with the NO synthase inhibitor L-NAME (20 mg/kg/day) in the presence or absence of Ang-(1-7). 29352340 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE While the beneficial effects of Ang-(1-7) have been widely studied in several experimental models of hypertension, much less studies were performed in experimental models of atherosclerosis. 29541937 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 AlteredExpression disease BEFREE Application of NaHS, an H<sub>2</sub>S donor considerably attenuated the severity of atherosclerosis with upregulating carotid expression of ACE2, thus converting pro-atherosclerotic angiotensin II (Ang II) to anti-atherosclerotic angiotensin 1-7 (Ang-(1-7)). 29066981 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE Ang-1 specifically increases circulating Gr1<sup>+ </sup>inflammatory monocytes and increases monocyte/macrophage retention in atherosclerotic plaques, thereby contributing to development of atherosclerosis. 28069704 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE Our results suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8. 28283184 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE The attenuation of Ang-(1-7) and losartan in atherosclerosis plaque formation was similar. 25957120 2015
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE ACE2 and Ang-(1-7) protect endothelial cell function and prevent early atherosclerosis by inhibiting inflammatory response. 25721616 2015
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE Ang (1-7) may, therefore, have therapeutic benefits for the treatment of atherosclerosis. 25779847 2015
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE Angiopoietin 1 (Angpt1) and angiopoietin 2 (Angpt2) are the ligands of tyrosine kinase (Tie) receptors, and they play important roles in vessel formation and the development of inflammatory diseases, such as atherosclerosis. 26283334 2015
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE These results demonstrate that ACE2 deficiency in bone marrow-derived cells promotes atherosclerosis through regulation of Ang II/Ang-(1-7) peptides. 21252069 2011