ANGPT1, angiopoietin 1, 284

N. diseases: 340; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE Taken altogether, our findings reveal a novel role for miR-204/ANGPT1/TGFβR2 axis in tumor angiogenesis. 27703260 2016
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE The effects of Ang-(1-7) on tumor proliferation and apoptosis were reversed by coadministration with A779 or PD123319, whereas the effects on tumor angiogenesis were completely reversed by A779 but not by PD123319. 26225830 2015
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE Vascular endothelial growth factor (VEGF) and Angiopoietins (Ang-1, Ang-2) have a pivotal role in tumor angiogenesis but few data regarding their role in hereditary breast cancer are available. 23232696 2013
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE Previous studies have demonstrated that Ang-(1-7) inhibits both the growth of human lung cancer cells in vitro and tumor angiogenesis in vivo through activation of the MAS receptor. 22089256 2012
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE To investigate the mechanisms of clearance of AMG 386, an investigational recombinant peptide-Fc fusion protein (peptibody) that blocks tumor angiogenesis by neutralizing the interaction between angiopoietin-1 and -2 and the Tie2 receptor. 22189693 2012
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE In this study, we used the Rip1Tag2 transgenic mouse model of pancreatic β-cell carcinogenesis to investigate the roles of Ang-1 and Ang-2 in tumor angiogenesis and tumor progression. 21778249 2011
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE This retarded MDA-MB-231 breast carcinoma growth in vitro and in vivo elicited by Ad-ING4 closely correlated with the upregulation of cell cycle-related molecules P21 and P27, decrease in the ratio of anti- to proapoptotic molecules Bcl-2/Bax, release of cytochrome c from mitochondria into cytosol followed by caspase-9 and -3 activation leading to apoptosis via intrinsic apoptotic pathway, and the reduced expression of proangiogenic factors IL-8 and Ang-1 involved in the inhibition of tumor angiogenesis. 20707719 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE The roles of Ang-1 and Ang-2 in tumor angiogenesis have been established. 20823154 2010
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE These results suggest that Ang-(1-7) may attenuate tumor angiogenesis by reducing vascular endothelial growth factor-A, a primary proangiogenic protein. 19509262 2009
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression phenotype BEFREE These findings indicate that the expression of Ang-1 and Ang-2 is important for tumor angiogenesis, and suggest a possible role of autocrine/paracrine function of angiopoietin/Tie2 system in gastric cancer progression. 16614513 2006
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression phenotype BEFREE In addition, we have demonstrated that the binding of Ang-3 to the cell surface is required for the effective inhibition of Ang-3 on tumor metastasis and that Ang-3 inhibits endothelial cell proliferation and survival and blocks Ang-1- and vascular endothelial growth factor-induced activation of extracellular signal-regulated kinase 1/2 and Akt kinases, which likely underlie the Ang-3-mediated inhibition on tumor angiogenesis and metastasis. 15342395 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. 15094228 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE The effects of Ang-1 on tumor angiogenesis remain controversial; although we have previously demonstrated that Ang-1 overexpression in colon cancer cells leads to a decrease in s.c. tumor growth, others have shown that Ang-1 may be proangiogenic. 12810673 2003
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE We discuss the enigmatic role of Ang1 in tumor angiogenesis in this review. 14672554 2003
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression phenotype BEFREE In this study, we investigated the expression of Ang-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in surgically resected specimens from 46 patients with HCC to determine their potential role in tumor angiogenesis and its progression. 12717391 2003
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE In two cell lines derived from human lung cancer, H460 and A549, both of which produce a considerable amount of FGF-2, sVEGFR and a soluble receptor for angiopoietin-1 were both ineffective; however, sFGFR1 inhibited tumor angiogenesis and growth, demonstrating the critical role that FGFs play in some cancers. 12136423 2002
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE These results indicate that angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. 12243755 2002
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker phenotype BEFREE Our results indicate that the perturbation of Ang1 expression in tumors could be an effective method to control tumor growth by inhibiting tumor angiogenesis and that antisense RNA is an efficient way to inhibit Ang1 protein production in tumor cells. 11668472 2001
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression phenotype BEFREE These data suggest that imbalances between Ang-1 and -2 that result in a net gain of Ang-2 activity lead to enhanced tumor angiogenesis and growth. 11245414 2001