Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Ang II (angiotensin II), a key pro-hypertensive hormone, mediates target organ consequences such as endothelial dysfunction and cardiac hypertrophy.
|
31838904 |
2020 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In Ang II-infused mice, mPGES-1 deletion prevented all of the following: (1) the augmented wall:lumen ratio, vascular stiffness, and altered elastin structure; (2) the increased gene expression of profibrotic and proinflammatory markers; (3) the increased vasoconstrictor responses and endothelial dysfunction; (4) the increased NADPH oxidase activity and the diminished mitochondrial membrane potential; and (5) the increased reactive oxygen species generation and reduced NO bioavailability.
|
29891646 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
IL-6 correlated positively with other inflammatory markers (white blood cell and neutrophil counts, C-reactive protein, procalcitonin), the markers of renal injury (kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin), and the markers of endothelial dysfunction (angiopoietin-2, soluble fms-like tyrosine kinase-1).
|
29925813 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results demonstrate that in Ang II-induced hypertensive rats, puerarin protects against endothelial dysfunction and end organ damage with a mild reduction in SBP, and that the cardiovascular beneficial effects of puerarin may be in part attributed to its anti-oxidant and upregulation of phosphor-eNOS.
|
28060542 |
2017 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Ang-2 and sTie-2 plasma levels are increased in pediatric OSA and obesity, particularly when endothelial dysfunction or insulin resistance is detectable, and appear to decrease upon OSA treatment.
|
28474375 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
BM transplantation revealed a role for immune cells in Ang II-induced BP elevation, and for both vascular and immune cell MMP2 in Ang II-induced endothelial dysfunction.
|
29016715 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Anti-TCRγδ antibody-induced γδ T-cell depletion blunted Ang II-induced SBP rise and endothelial dysfunction (<i>P</i><0.05), compared with isotype antibody-treated Ang II-infused mice.
|
28330983 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) were proposed as markers of endothelial dysfunction in acute states.
|
28368336 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In mice, deletion of P2Y6R attenuated Ang II-induced increase in blood pressure, vascular remodeling, oxidative stress, and endothelial dysfunction.
|
26787451 |
2016 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Angiotensin (Ang) II plays an important role in the process of endothelial dysfunction in acute lung injury (ALI) and is degraded by angiotensin-converting enzyme2 (ACE2).
|
25200929 |
2015 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Angiotensin II (Ang II) is essential for endothelial progenitor cells (EPCs) function as Ang-II-induced oxidative stress causes senescence of EPCs and endothelial dysfunction and Ang II type 1 receptor blockers increase EPCs.
|
21654754 |
2011 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.
|
20562294 |
2010 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
One of the main effectors of endothelial dysfunction is ANG II, and pharmacological approaches to limit ANG II bioactivity remain the cornerstone of cardiovascular therapeutics.
|
18660448 |
2008 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Ang II-induced endothelial dysfunction is associated with increased oxidative stress and vascular xanthine oxidase activity.
|
11230310 |
2001 |