Seizures
|
0.410 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.
|
31353024 |
2019 |
Seizures
|
0.410 |
GeneticVariation
|
phenotype |
BEFREE |
The affected mother had a history of hydrocephalus, developmental delay, and seizures commonly associated with DLL1 and TBP 6q27 deletions.
|
30194807 |
2018 |
Seizures
|
0.410 |
Biomarker
|
phenotype |
HPO |
|
|
|
Scoliosis, unspecified
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.
|
31353024 |
2019 |
Intellectual Disability
|
0.400 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Given that Delta-like 1 (DLL1) is a ligand for the Notch receptor and that a few individuals with developmental delay, intellectual disability, and brain malformations have microdeletions encompassing DLL1, we hypothesized that insufficiency of DLL1 causes a human neurodevelopmental disorder.
|
31353024 |
2019 |
Scoliosis, unspecified
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
Intellectual Disability
|
0.400 |
Biomarker
|
group |
HPO |
|
|
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Consistent with prognostic clinical data, we found the tumor-promoting function of DLL1 is exclusive to ERα<sup>+</sup> luminal breast cancer, as loss of DLL1 inhibits both tumor growth and lung metastasis of luminal breast cancer.
|
30442981 |
2019 |
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Delta-like1 (DLL1) is a ligand of the Notch pathway implicated in different types of cancer, including breast cancer.
|
29366964 |
2018 |
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
In gain-of-function and loss-of-function studies, we demonstrated that miR-130b-3p could inhibit breast carcinoma cell invasion and migration by directly targeting the Notch ligand Delta-like 1 (DLL1).
|
28163094 |
2017 |
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.
|
21036696 |
2010 |
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
Consistent with prognostic clinical data, we found the tumor-promoting function of DLL1 is exclusive to ERα<sup>+</sup> luminal breast cancer, as loss of DLL1 inhibits both tumor growth and lung metastasis of luminal breast cancer.
|
30442981 |
2019 |
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
Delta-like1 (DLL1) is a ligand of the Notch pathway implicated in different types of cancer, including breast cancer.
|
29366964 |
2018 |
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
CTD_human |
Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.
|
21036696 |
2010 |
Global developmental delay
|
0.310 |
Biomarker
|
disease |
BEFREE |
Given that Delta-like 1 (DLL1) is a ligand for the Notch receptor and that a few individuals with developmental delay, intellectual disability, and brain malformations have microdeletions encompassing DLL1, we hypothesized that insufficiency of DLL1 causes a human neurodevelopmental disorder.
|
31353024 |
2019 |
Global developmental delay
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Given that Delta-like 1 (DLL1) is a ligand for the Notch receptor and that a few individuals with developmental delay, intellectual disability, and brain malformations have microdeletions encompassing DLL1, we hypothesized that insufficiency of DLL1 causes a human neurodevelopmental disorder.
|
31353024 |
2019 |
Autistic Disorder
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.
|
31353024 |
2019 |
Abnormal behavior
|
0.300 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.
|
31353024 |
2019 |
Morphological abnormality of the central nervous system
|
0.300 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.
|
31353024 |
2019 |
MENTAL RETARDATION, AUTOSOMAL DOMINANT 40
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.
|
31353024 |
2019 |
Brain Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
|
21127729 |
2010 |
Malignant neoplasm of brain
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
|
21127729 |
2010 |
Benign neoplasm of brain, unspecified
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
|
21127729 |
2010 |
Brain Tumor, Primary
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
|
21127729 |
2010 |
Recurrent Brain Neoplasm
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
|
21127729 |
2010 |