|
Liver Cirrhosis, Alcoholic
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is increasingly recognized by providers that patients and their families seek to reduce the stigma of alcoholic liver disease, and a change from the term "alcoholic" to "alcohol-related" will help; thus, alcohol-related liver disease, alcohol-related steatohepatitis, and alcohol-related cirrhosis are suggested, retaining the familiar abbreviations (ALD, ASH, and AC, respectively).
|
31314133 |
2020 |
|
Ataxia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Orally administered ASH-WEX significantly suppressed the cognitive and motor-coordination impairments in rats.
|
31416451 |
2019 |
|
Hematological Disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These results, in concert, indicate that the B19V 11-kDa protein interacts with cellular Grb2 to downregulate ERK activity, which upregulates viral DNA replication.<b>IMPORTANCE</b> Human parvovirus B19 (B19V) infection causes hematological disorders and is the leading cause of nonimmunological fetal hydrops during pregnancy.
|
30282717 |
2019 |
|
Hydrops Fetalis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results, in concert, indicate that the B19V 11-kDa protein interacts with cellular Grb2 to downregulate ERK activity, which upregulates viral DNA replication.<b>IMPORTANCE</b> Human parvovirus B19 (B19V) infection causes hematological disorders and is the leading cause of nonimmunological fetal hydrops during pregnancy.
|
30282717 |
2019 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we demonstrate that Grb2, HGAL, and Syk interact in the same complex, but Grb2 does not modulate the effects of HGAL on Syk kinase activity.
|
31362927 |
2019 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, <i>in vivo</i> experiments revealed that LINC01234 shRNA could serve as a tumor suppressor through down-regulating GRB2 in MM.
|
31737211 |
2019 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction.
|
31220469 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that 11-kDa specially interacts with cellular growth factor receptor-bound protein 2 (Grb2) during virus infection and <i>in vitro</i> We determined a high affinity interaction between 11-kDa and Grb2 that has an equilibrium dissociation constant (<i>K<sub>D</sub></i> ) value of 18.13 nM.
|
30282717 |
2019 |
|
Rhabdoid Tumor of the Kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
The receptor tyrosine kinase (RTK) signal pathway plays an important role in the process of SSc, and Grb2 associated binding protein (GAB) is crucial in activating RTK signaling.
|
31505074 |
2019 |
|
Adult Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrate that Grb2, HGAL, and Syk interact in the same complex, but Grb2 does not modulate the effects of HGAL on Syk kinase activity.
|
31362927 |
2019 |
|
Childhood Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrate that Grb2, HGAL, and Syk interact in the same complex, but Grb2 does not modulate the effects of HGAL on Syk kinase activity.
|
31362927 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Toward the main theme of "Frontiers in ASH, NASH, NBNC-HCC and PDAC", this platform showcased presentations by 12 invited international and Japanese speakers on brain-gut-liver interactions, emerging mechanisms of ASH and NASH, metabolic reprogramming, and new therapeutic targets for cirrhosis, HCC, and PDAC.
|
30643981 |
2019 |
|
Parvovirus B19 (disease)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The 11-Kilodalton Nonstructural Protein of Human Parvovirus B19 Facilitates Viral DNA Replication by Interacting with Grb2 through Its Proline-Rich Motifs.
|
30282717 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2.
|
31719636 |
2019 |
|
Eosinophilia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on these findings pharmacologic GRB2 inhibitors may have the potential to dampen tissue eosinophilia in various eosinophil-associated diseases.
|
30183074 |
2018 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
We demonstrate the ability of digoxin, a cardiac glycoside, to protect from liver inflammation and damage in ASH and NASH.
|
29414684 |
2018 |
|
HIV Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In those with HCV/HIV infection, nearly 40% carry gene polymorphisms associated with the development of NASH or ASH.
|
30218427 |
2018 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The future of chronic lymphocytic leukemia: potential directions from ASH 2017.
|
29791237 |
2018 |
|
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
This has major clinical consequences, for alcoholic and non-alcoholic steatohepatitis (ASH and NASH) account for the majority of liver disease in industrialized countries and both lack therapy.
|
29414684 |
2018 |
|
Dyggve-Melchior-Clausen syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blotting showed that DMC significantly reduced protein levels of GRB2, MMP-2, ERK1/2, N-cadherin and Ras but increased the levels of E-cadherin and NF-κB in HeLa cells.
|
29715097 |
2018 |
|
Hyperactive behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
This, in turn, alters the availability of phospho-ITT to trigger longer adaptor protein Grb2 dwell times in immunological synapses, leading to hyper-Grb2-Bruton's tyrosine kinase (Btk) signaling upon antigen binding.
|
30287618 |
2018 |
|
Eosinophilic disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Based on these findings pharmacologic GRB2 inhibitors may have the potential to dampen tissue eosinophilia in various eosinophil-associated diseases.
|
30183074 |
2018 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This has major clinical consequences, for alcoholic and non-alcoholic steatohepatitis (ASH and NASH) account for the majority of liver disease in industrialized countries and both lack therapy.
|
29414684 |
2018 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression and biological function of Grb2-associated binding 2 (Gab2) in renal cell carcinoma (RCC) cells was tested here.
|
28412750 |
2017 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Variants in or near AFF3, RGMA-MCTP2, SP3-CDCA7, GLRA3, CNKSR3, and UMOD have reached genome-wide significance (p value <5 × 10<sup>-8</sup>) for association with diabetic kidney disease, and recently, GRB2 was reported to be associated at genome-wide significance with diabetic retinopathy.
|
28779365 |
2017 |