GRB2, growth factor receptor bound protein 2, 2885

N. diseases: 122; N. variants: 8
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.020 GeneticVariation disease BEFREE In the present study, we examined a potential genetic association between the variant rs7219 within the 3'-UTR of GRB2 and the susceptibility to schizophrenia (SCZ) and bipolar disorder (BD) in the Chinese Han population. 30474799 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.020 Biomarker disease BEFREE Two pathways showed a significant enrichment after correction for multiple comparisons in the GSEA: GRB2 events in ERBB2 signaling, for which 6 of 21 genes were BD associated (P<sub>FDR</sub> = 0.0377), and NCAM signaling for neurite out-growth, for which 11 out of 62 genes were BD associated (P<sub>FDR</sub> = 0.0451). 29197740 2018