Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE The Role of Grb2 in Cancer and Peptides as Grb2 Antagonists. 29173143 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 AlteredExpression group BEFREE Using mutants of BTLA signaling motifs, we uncovered a costimulatory function mediated by Grb2 through enhancing the secretion of IL-2 and the activation of Src after TCR stimulation.<b>Conclusions:</b> Our data portrays BTLA as a molecule with the singular ability to provide both costimulatory and coinhibitory signals to activated CD8<sup>+</sup> T cells, resulting in extended survival, improved tumor control, and the development of a functional recall response.<i>Clin Cancer Res; 23(20); 6151-64.©2017 AACR</i>. 28754817 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE Grb2‑associated binder 2 (Gab2) has been reported to serve important roles in the progression of various types of human cancer. 28791340 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE These findings suggest a novel pathway leading to cancer MDR, in which Snail induces EMT concomitantly with a decrease in GRB2-mediated caveolin-1 phosphorylation, resulting in activation of P-gp. 28322937 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE Grb2-associated binding protein 2 (GAB2) is a member of the daughter of sevenless/Gab family of scaffolding adapters, and has been reported to be important in the development and progression of human cancer. 27035789 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE The growth factor receptor bound protein 2 (Grb2) is one of the affirmative targets for cancer therapy, especially for breast cancer. 23314696 2013
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE Fusion protein based on Grb2-SH2 domain for cancer therapy. 20655296 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE These data provide genetic evidence for a mammalian Grb2-Ras signaling pathway, mediated by SH2/SH3 domain interactions, that has multiple functions in embryogenesis and cancer. 9865697 1998