GRB2, growth factor receptor bound protein 2, 2885

N. diseases: 122; N. variants: 8
Disease: Primary malignant neoplasm of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.010 Biomarker disease BEFREE We evaluated response to crizotinib in a <i>MET</i>-amplified cohort of PDX models of lung cancer (<i>N</i> = 6) and provide a case report of a lung cancer patient harboring a Δexon14 <i>MET</i> splice variant.<b>Results:</b> We found the interaction of MET with the adaptor protein GRB2 is necessary for oncogenic survival signaling by MET. 28855353 2017