Mental Depression
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression.
|
22534499 |
2012 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
BEFREE |
Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit.
|
29246976 |
2018 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
BEFREE |
PS-induced reduction of GluA1-3 subunits of AMPARs may be an important potential mechanism of offspring depression.
|
29019029 |
2017 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
PSYGENET |
βCaMKII in lateral habenula mediates core symptoms of depression.
|
23990563 |
2013 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
BEFREE |
Our study reveals that the CTDs of GluA1 and GluA2, the key subunits of AMPARs, are necessary and sufficient to drive NMDA receptor-dependent LTP and LTD, respectively.
|
29230056 |
2018 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
BEFREE |
GluA1 endocytosis following chemically-induced LTD was also impaired in Stim2 cKO neurons.
|
27544849 |
2017 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Our results provide evidence for a significant role of hippocampal GluA1-containing AMPA receptors and their PDZ-interaction in experience-dependent expression of behavioral despair and link mechanisms of hippocampal synaptic plasticity with behavioral expression of depression.
|
23262314 |
2013 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
BEFREE |
Here we show that tamoxifen-induced GluA1 deletion restricted to forebrain glutamatergic neurons of post-adolescent mice does not induce depression- and anxiety-like changes.
|
24895223 |
2014 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment.
|
24725413 |
2014 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
PSYGENET |
The role of GluA1 in ocular dominance plasticity in the mouse visual cortex.
|
24048851 |
2013 |
Mental Depression
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Here we show that tamoxifen-induced GluA1 deletion restricted to forebrain glutamatergic neurons of post-adolescent mice does not induce depression- and anxiety-like changes.
|
24895223 |
2014 |
Mental Depression
|
0.380 |
PosttranslationalModification
|
disease |
BEFREE |
Synaptic transmission efficacy can be bi-directionally modified through potentiation (long-term potentiation (LTP)) or depression (long-term depression (LTD)) as well as the phosphorylation state of Ser831 and Ser845 sites at the GluA1 subunit of the glutamate AMPA receptors, which has been characterized as a critical event for this synaptic plasticity.
|
29880883 |
2020 |
Mental Depression
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
The (2R,6R)-HNK concentrations that increased GluA1 expression are consistent with its maximal C<sub>b,u</sub> (0.92-4.84 μM) at reportedly efficacious doses of ketamine or (2R,6R)-HNK in mouse depression models, but ≥3-fold above its projected maximal human C<sub>b,u</sub> (≤37.8 ± 14.3 nM) following ketamine's clinically antidepressant infusion.
|
31015046 |
2019 |