GRN, granulin precursor, 2896

N. diseases: 412; N. variants: 66
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4551584
Disease: Brain atrophy
Brain atrophy
0.170 GeneticVariation disease BEFREE Plasma progranulin levels predict the presence of GRN null mutations independent of proximity to symptoms and brain atrophy. 29146050 2018
CUI: C4551584
Disease: Brain atrophy
Brain atrophy
0.170 Biomarker disease BEFREE Participants from the Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; n = 1,239), with both MRI scans and genotype data, were used to assess the association between brain atrophy and previously identified HS-Aging risk SNPs in the following genes: GRN, TMEM106B, ABCC9, and KCNMB2 (minor allele frequency for each is >30%). 27003218 2016
CUI: C4551584
Disease: Brain atrophy
Brain atrophy
0.170 Biomarker disease BEFREE Progressive brain atrophy was observed in all groups, with fastest rates of whole brain atrophy in GRN, followed by sporadic FTD, C9ORF72 and MAPT. 25683866 2015
CUI: C4551584
Disease: Brain atrophy
Brain atrophy
0.170 GeneticVariation disease BEFREE Carriers of the GRN mutation are characterized by a variable degree of asymmetric brain atrophy, predominantly in the frontal, temporal, and parietal lobes. 25317628 2014
CUI: C4551584
Disease: Brain atrophy
Brain atrophy
0.170 GeneticVariation disease BEFREE We aimed to determine the regional pattern of brain atrophy associated with the C9ORF72 gene mutation, and to determine which regions best differentiate C9ORF72 from subjects with mutations in tau and progranulin, and from sporadic frontotemporal dementia. 22366795 2012
CUI: C4551584
Disease: Brain atrophy
Brain atrophy
0.170 Biomarker disease BEFREE Rates of whole brain atrophy in GRN, and hippocampal atrophy in MAPT, were associated with age, with older subjects showing slower rates of atrophy (p = 0.01 and p < 0.001). 21753165 2011
CUI: C4551584
Disease: Brain atrophy
Brain atrophy
0.170 GeneticVariation disease BEFREE Brain volumes were smaller in the GRN group with a faster rate of whole-brain atrophy. 20045477 2010
CUI: C4551584
Disease: Brain atrophy
Brain atrophy
0.170 Biomarker disease HPO