|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NOB1 mRNA relative expression in cancer tissue was 4.899∓1.412.
|
26122232 |
2015 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Results of a previous study demonstrated that downregulation of NIN1/RPN12 binding protein 1 homolog (NOB1) expression via adenovirus expression vector carrying NOB1 siRNA (Ad/sh-NOB1) induced cancer apoptosis and increased the radiosensitivity of papillary thyroid carcinoma (PTC) cells.
|
25592304 |
2015 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of NOB1 in cancer and cancer-adjacent tissues of patients was detected by reverse transcription-polymerase chain reaction, and the relationship between NOB1 expression and the pathogenesis of osteosarcoma was analyzed.
|
29467874 |
2018 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Nin one binding protein (NOB) 1 has been reported to be involved in cancer.
|
25503472 |
2015 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Nin one binding (NOB1) gene has been reported up-regulated in several types of cancer.
|
24272676 |
2014 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
This review summarizes the research progress made into NOB1 in cancer in the past decade; this information provides valuable clues and theoretical guidance for future anticancer therapy by targeting NOB1.
|
30854959 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study evaluates whether NOB1 is an appropriate molecular target for cancer gene therapy.
|
21287298 |
2012 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
NOB1 was reported to be involved in the development of several types of cancer.
|
26370469 |
2015 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
MiR-326 inhibited colony formation in soft agar and decreased growth of a xenograft tumor model, suggesting that miR-326 and NOB1 are required for tumorigenesis in vitro and in vivo.
|
23869222 |
2013 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
In addition, the colony formation and tumor growth ability in nude mice were detected to define the function of Nob1 in cell transformation and tumorigenesis.
|
21573803 |
2012 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Long non-coding RNA SNHG1 regulates NOB1 expression by sponging miR-326 and promotes tumorigenesis in osteosarcoma.
|
29115574 |
2018 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Using a xenograft tumour model, we observed the in vivo tumorigenesis effect of miR-646 and NOB1.
|
25010867 |
2014 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
In summary, our present study clarify that the aberrant expression of NOB1 in breast infiltrating ductal carcinoma is possibly involved with tumorigenesis and development, and the NOB1 protein could act as a potential biomarker for prognosis assessment of breast infiltrating ductal carcinoma.
|
24133592 |
2013 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
NOB1 and p38 MAPK expression had significant positive correlation with carcinogenesis, tumor progression and patient survival.
|
24228091 |
2013 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
In addition, tumor growth ability in nude mice was evaluated to define the function of NOB1 in cell transformation and tumorigenesis.
|
24452698 |
2014 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Long non-coding RNA ZFAS1 regulates NOB1 expression through interacting with miR-646 and promotes tumorigenesis in osteosarcoma.
|
31081072 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
These data suggest that NOB1 is an important regulator of the tumorigenic properties of human NSCLC and may be used as a new promising diagnostic biomarker and a potential anticancer therapeutic target for NSCLC.
|
24452698 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
In our previous study, RIOK2 and NOB1 were revealed to be highly expressed in NSCLC, and were associated with the clinicopathological characteristics of patients with NSCLC, i.e.
|
29749434 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that enhanced expression of NOB1 gene plays an important role in the occurrence and development of NSCLC.
|
24272676 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results indicate that miR-330-5p inhibits NSCLC cell growth through downregulation of NOB1 expression.
|
28849232 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest the risk scores based on p-Akt, VEGF, NOB1 expression can predict postoperative survival in patients with resected NSCLC.
|
26884885 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results suggest that NOB1 may act as an important regulator in non-small cell lung cancer growth and could be a therapeutic target of non‑small cell lung cancer.
|
26178254 |
2015 |
|
Neoplasm Metastasis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Thus, for the first time, we provide convincing evidence that downregulation of miR-326 inhibited tumor proliferation and tumor metastasis by directly targeting NOB1 in CRC.
|
25760058 |
2015 |
|
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
In the present study, using quantitive real-time PCR and immunohistochemistry. we initially found that expression of the ribosome assembly factor NIN/RPN12 binding protein (NOB1) was elevated in the majority of NSCLC tissues when compared to that in the normal lung tissue counterparts, and its expression level was correlated with key pathological characteristics including tumor differentiation, stage and metastasis.
|
24452698 |
2014 |
|
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
NOB1 expression was significantly correlated with Gleason score (P<0.001) and distant metastasis (P<0.001).
|
25503472 |
2015 |