|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We conducted a case-control study to investigate the association between the GRIN1 gene, which encodes the NR1 subunit, and the risk of schizophrenia in a northern Chinese Han population using Sanger DNA sequencing.
|
30704411 |
2019 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Because abnormalities of cortical GABAergic interneurons lie at the core of the pathophysiology of schizophrenia, we examined whether mGlu3 receptors influence the developmental trajectory of cortical GABAergic transmission in the postnatal life. mGlu3<sup>-/-</sup> mice showed robust changes in the expression of interneuron-related genes in the prefrontal cortex (PFC), including large reductions in the expression of parvalbumin (PV) and the GluN1 subunit of NMDA receptors.
|
31665922 |
2019 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
We administered a PPAR agonist to the GluN1 knockdown model of schizophrenia and found it improved long-term memory.
|
30338483 |
2019 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
NFL is known to interact with the GluN1 subunit of N-methyl-D-aspartic acid (NMDAR) and be reduced in schizophrenia though functional consequences are unknown.
|
30143609 |
2018 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mice with pyramidal cell-selective knockout of ionotropic glutamate receptors (GluN1) were used to reproduce a prominent physiological change involved in schizophrenia.
|
29350251 |
2018 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
PSD-95 beta transcript was increased (t = 3.346, df = 14, P < .05) in the GluN1 KD mouse model of schizophrenia.
|
28126896 |
2017 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Recent reports have demonstrated that polymorphism in the promoter region of GRIN1 at position -855 (G/C) has a possible association with schizophrenia.
|
28702665 |
2017 |
|
Schizophrenia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In schizophrenia compared to unaffected controls the pooled effect size was -0.64 (95% confidence interval: -1.08 to -0.20) for NR1 mRNA reduction and -0.44 (95% confidence interval: -0.80 to -0.07) for NR1 protein reduction.
|
26549579 |
2016 |
|
Schizophrenia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Methamphetamine (METH) is a psychostimulant drug which can induce psychotic symptoms reminiscent of those found in schizophrenia; thus GRIN1 is a candidate gene for vulnerability to METH dependence or METH-dependent psychosis.
|
23880023 |
2013 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine (1) whether SNP variation in the genes (GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) encoding the NMDA receptor were associated with schizophrenia; (2) whether GRIN gene variation in the offspring interacted with maternal herpes simplex virus-2 (HSV-2) seropositivity during pregnancy influencing the risk of schizophrenia later in life.
|
21919190 |
2011 |
|
Schizophrenia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In summary, our study suggests that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients.
|
20204507 |
2010 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In this report, we used a case control study to establish the possible association between the G1001C polymorphism in the GRIN1 gene promoter region and schizophrenia in an Iranian cohort of 200 unrelated patients and 200 controls.
|
18792810 |
2009 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia.
|
17728671 |
2007 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
The glutamatergic hypothesis of schizophrenia lead recently to a first successful mGlu2/3 receptor agonistic drug and is underpinned by significant findings in genes regulating the glutamatergic system (SLC1A6, SLC1A2 GRIN1, GRIN2A, GRIA1, NRG1, ErbB4, DTNBP1, DAAO, G72/30, GRM3).
|
17982252 |
2007 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Given previous evidence of Layer II/III and V pyramidal cell alterations in schizophrenia and the significant influence of subunit composition on NMDA and AMPA receptor function, laser capture microdissection combined with quantitative PCR was used to examine the expression of AMPA (GRIA1-4) and NMDA (GRIN1, 2A and 2B) subunit mRNA levels in Layer II/III and Layer V pyramidal cells in the DLPFC.
|
17942280 |
2007 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Two NMDA receptor subunit genes, GRIN1 and GRIN2A, are both good candidate genes for schizophrenia.
|
16476413 |
2006 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray.
|
15841096 |
2005 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
These findings suggest that the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.European Journal of Human Genetics (2005) 13, 807-814. doi:10.1038/sj.ejhg.5201418 Published online 20 April 2005.
|
15841096 |
2005 |
|
Schizophrenia
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.
|
14973229 |
2004 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
MGD |
Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function.
|
15265649 |
2004 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the NMDAR1 subunit is not frequently involved in the development of schizophrenia in the German population.
|
15564900 |
2004 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
The association reported in this study suggests that the GRIN1 gene is a good candidate for the susceptibility to schizophrenia.
|
12679240 |
2003 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We tested the hypothesis that GRIN1 polymorphisms were associated with schizophrenia using the transmission disequilibrium test (TDT) and comparing allele frequencies between cases and controls.
|
12707933 |
2003 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the human GRIN1 gene may not contribute substantially to the genetic etiology of schizophrenia in our population.
|
12454527 |
2002 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
In an examination of the NMDAR1 as a candidate gene in schizophrenia, a presumed microdeletion/insertion (del/ins) was observed in intron 10 of an African-American male near a weak putative branch-site consensus sequence.
|
12210277 |
2002 |