Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.340 AlteredExpression phenotype BEFREE Collectively these results demonstrate that spinal nNOS-PSD95 interactions play an important role in PKC-dependent GluN1 phosphorylation via activation of the PKC-ε isoform, and ultimately contributes to the development of MA in peripheral neuropathy. 30926374 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.340 Biomarker phenotype BEFREE Collectively, we show that spinal D-serine modulates nNOS activity and concomitant NO production leading to increases in PKC-dependent pGluN1 and ultimately contributing to the induction of mechanical allodynia following peripheral nerve injury. 30900515 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.340 GeneticVariation phenotype BEFREE Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain. 27986591 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.340 Biomarker phenotype BEFREE We conducted this study to investigate the protective effect of GSH in CPIP rats via changes of mechanical allodynia and phospholyration of the N-methyl-D-aspartate receptor subunit GluN1. 29209138 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.340 Biomarker phenotype CTD_human Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. 27093858 2016