|
Bipolar Disorder
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
Two of these showed differential expression in the CC of BD cases: RPS23 was significantly down-regulated (p = 0.0036, fc = 0.80), while GRIN2A showed suggestive evidence of down-regulation in BD (p = 0.056, fc = 0.65).
|
31652432 |
2019 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies 30 loci associated with bipolar disorder.
|
31043756 |
2019 |
|
Bipolar Disorder
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
Genetic studies point to the genes encoding the NMDA 1, 2A and 2B subunits while neuropathological studies suggest a possible region specific decrease in the density of NMDA receptor and more consistently a reduced NMDA-mediated glutamatergic activity in patients with bipolar disorder in the frame of slower NMDA kinetics because of lower contribution of NR2A subunits.
|
22280433 |
2012 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
PSYGENET |
Genetic studies point to the genes encoding the NMDA 1, 2A and 2B subunits while neuropathological studies suggest a possible region specific decrease in the density of NMDA receptor and more consistently a reduced NMDA-mediated glutamatergic activity in patients with bipolar disorder in the frame of slower NMDA kinetics because of lower contribution of NR2A subunits.
|
22280433 |
2012 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
PSYGENET |
These findings suggest that, in the PFC, glutamatergic regulation of PV-containing inhibitory neurons via NR2A-containing NMDA receptors does not appear to be altered in bipolar disorder.
|
20148871 |
2010 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
BEFREE |
We used double in situ hybridization with a sulfur-35-labeled riboprobe for the NR2A subunit of the NMDA receptor and a digoxigenin-labeled riboprobe for PV in a cohort of 18 subjects with bipolar disorder and 18 demographically matched normal control subjects.
|
20148871 |
2010 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
BEFREE |
Previously, we found that, in the anterior cingulate cortex (ACCx), the number of GABA cells that expressed the messenger RNA (mRNA) for the NMDA NR2A subunit was significantly decreased in subjects with schizophrenia and bipolar disorder and that this decrease occurred most prominently in layer 2.
|
18585682 |
2008 |
|
Bipolar Disorder
|
0.580 |
GeneticVariation
|
disease |
BEFREE |
In a cohort of postmortem human brains from schizophrenia (n=20), bipolar disorder (n=20) and normal control (n=20) subjects, we colocalized the mRNA for the N-methyl-d-aspartate (NMDA) receptor NR2A subunit, labeled with [35S], and the mRNA for the gamma-aminobutyric acid (GABA) synthesizing enzyme glutamic acid decarboxylase (GAD)67, labeled with digoxigenin.
|
18534564 |
2008 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
PSYGENET |
However, compared with the normal control subjects and subjects with bipolar disorder, the density of CB+/NR2A+ neurons in layer 2 was increased by 41% to 44 % in subjects with schizophrenia, whereas the amount of NR2A mRNA/CB+ neurons was unchanged.
|
18585682 |
2008 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
PSYGENET |
In addition, the density of the GAD67+/NR2A+ neurons was decreased by 57% and 49% in layers 3 and 4, respectively, in schizophrenia, but it was unchanged in bipolar disorder.
|
18534564 |
2008 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
BEFREE |
In the perirhinal cortex we detected decreased expression of GluR5 in all three diagnoses, of GluR1, GluR3, NR2B in both BD and MDD, and decreased NR1 and NR2A in BD and MDD, respectively.
|
17299517 |
2007 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
BEFREE |
There was a significant decrease in the expression of transcripts for NR1 and NR2A subunits and SAP102 in bipolar disorder.
|
17113057 |
2007 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
PSYGENET |
In the perirhinal cortex we detected decreased expression of GluR5 in all three diagnoses, of GluR1, GluR3, NR2B in both BD and MDD, and decreased NR1 and NR2A in BD and MDD, respectively.
|
17299517 |
2007 |
|
Bipolar Disorder
|
0.580 |
Biomarker
|
disease |
BEFREE |
There is also growing evidence for the role of DRD1, NMDA receptor genes (GRIN1, GRIN2A, GRIN2B), brain-derived neurotrophic factor (BDNF), and dopamine transporter (SLC6A3) in both schizophrenia and bipolar disorder.
|
15952869 |
2005 |