Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Magnesium and ketamine have a common mechanism of action in the treatment of depression: an increase in GluN2B (NMDAR subunit) expression is related to the administration of both of the agents, as well as inhibition of phosphorylation of eEF2 (eukaryotic elongation factor 2) in cell culture and increase of the expression of BDNF in the hippocampus.
|
31488789 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The interaction of death-associated protein kinase <b>1</b> (DAPK1) with the 2B subunit (GluN2B) C-terminus of N-methyl-D-aspartate receptor (NMDAR) plays a critical role in the pathophysiology of depression and is considered a potential target for the structure-based discovery of new antidepressants.
|
30463177 |
2018 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Altogether, our findings suggest that the DAPK1 interaction with the NMDAR GluN2B subunit acts as a critical component in the pathophysiology of depression and is a potential target for new antidepressant treatments.
|
28439098 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Downregulation of Egr-1 Expression Level via GluN2B Underlies the Antidepressant Effects of Ketamine in a Chronic Unpredictable Stress Animal Model of Depression.
|
29294341 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Collectively, these results suggest that CCL2/CCR2 signaling in the NAc shell is important in mediating neuropathic pain and depression via regulating NR2B-mediated NMDAR function in D1R- and D2R-containing neurons following peripheral nerve injury.
|
29993042 |
2018 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The effects common to ketamine and NR2B-selective compounds were localized to the same brain regions as those reported in depression, but in the opposite direction.
|
29305627 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Ketamine can improve expression of NR2B, LTP induction and NMDA receptor-mediated EPSCs in the hippocampus of depression-like mice, which might be part of the reason why ketamine can alleviate the memory dysfunction induced by depression.
|
30356718 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, decreased GR nuclear translocation with normal mechanical nociception and hypoalgesia of thermal nociception were observed in OB-Sham rats.Intrathecal injection (i.t.) of GR agonist dexamethasone (Dex; 4 μg/rat/day for 1 week) eliminated the attenuating effect of depression on nociceptive hypersensitivity in OB-SNL rats and aggravated neuropathic pain in NOB-SNL rats, which was associated with the up-regulation of brain-derived neurotrophic factor (BDNF), TrkB and NR2B expression in the spinal dorsal horn.
|
28579944 |
2017 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Negative regulation of DAPK1/GluN2B binding by Ca<sup>2+</sup>/CaM results in synaptic DAPK1 removal during LTP but retention during LTD. A pharmacogenetic approach showed that suppression of CaMKII/GluN2B binding is a DAPK1 function required for LTD.
|
28614711 |
2017 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here, using the chronic mild stress (CMS) paradigm of depression, we found that, independently from the anhedonic phenotype, CMS rats showed a deficit in the novel object recognition (NOR) test, which is associated with an inability to phosphorylate GluN2B subunit on Ser1303 and to activate the mTOR pathway.
|
28094500 |
2017 |
Depressed mood
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
Indeed, we observed a significant reduction of NMDA-induced field excitatory postsynaptic potential depression in the hippocampus of Tau mice together with a reduced phosphorylation of NR2B at the Y1472, known to be critical for NMDAR function.
|
23082852 |
2013 |