Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease LHGDN These findings suggest that the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.European Journal of Human Genetics (2005) 13, 807-814. doi:10.1038/sj.ejhg.5201418 Published online 20 April 2005. 15841096 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease LHGDN It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication. 11807413 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins. 28283559 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia. 15211626 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE It is necessary to explain the inconsistency of these results and to clarify the contribution of the GRIN2B gene to schizophrenia. 17224684 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE GRIN2B variants were genotyped using standard TaqMan procedures in 175 European patients with schizophrenia deemed resistant or intolerant to treatment. 26876050 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE The significant associations and interactions were located at the 3' region of GRIN2B suggesting that genetic variation in this part of the gene may be involved in the pathophysiology of schizophrenia. 21919190 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Variations in the N-methyl-d-aspartate receptor 2B subunit gene (GRIN2B) have been associated with schizophrenia, a psychiatric disorder associated with reduced left-hemispheric language dominance. 21827795 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia. 17669510 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE In this study, we performed a case-control study to identify polymorphisms of the GRIN2B gene that may confer susceptibility to SZ in the Han Chinese population. 26020650 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE To further examine the association between mutations in GRIN2B and SCZ/ASD development, a larger sample size and functional experiments are needed. 27616045 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease LHGDN These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia. 15211626 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease LHGDN These findings suggest that the T-200G variant causes dysfunction of NMDA receptors consisting of the NR2B subunit and may be involved in the development of schizophrenia. 12476325 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Although we did not detect NMDAR2B protein variants, our findings support the possibility that the GRIN2B gene or a locus in linkage disequilibrium with it may confer susceptibility to schizophrenia. 11317224 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE The present results support the hypothesis that rare de novo mutations in GRIN2A or GRIN2B can be associated with cases of sporadic SCZ or ASD, just as it has recently been described for the related neurodevelopmental disease intellectual disability. 22833210 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE In this study, we investigated whether single nucleotide polymorphisms (SNPs) in GRIN2B were associated with schizophrenia. 27453061 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE These findings suggest that the T-200G variant causes dysfunction of NMDA receptors consisting of the NR2B subunit and may be involved in the development of schizophrenia. 12476325 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE A surprising number of variants have been found in the N-methyl-d-aspartate receptor (NMDAR) gene family, with the GRIN2B gene encoding the GluN2B subunit being implicated in many cases of neurodevelopmental disorders, which are psychiatric conditions originating in childhood and include language, motor, and learning disorders, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), developmental delay, epilepsy, and schizophrenia. 27818011 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE The findings provided no evidence of an association between schizophrenia and the 2664C/T polymorphism of the NR2B subunit gene. 10910800 2000
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease CTD_human Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. 18583979 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease LHGDN The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder. 16549338 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication. 11807413 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. 15841096 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE <i>N</i>-Methyl D-aspartate receptor subtype 2B (NR2B)-containing NMDAR are associated with cognitive dysfunction in schizophrenia. 29695955 2018