|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The findings provided no evidence of an association between schizophrenia and the 2664C/T polymorphism of the NR2B subunit gene.
|
10910800 |
2000 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although we did not detect NMDAR2B protein variants, our findings support the possibility that the GRIN2B gene or a locus in linkage disequilibrium with it may confer susceptibility to schizophrenia.
|
11317224 |
2001 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication.
|
11807413 |
2001 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication.
|
11807413 |
2001 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These findings suggest that the T-200G variant causes dysfunction of NMDA receptors consisting of the NR2B subunit and may be involved in the development of schizophrenia.
|
12476325 |
2002 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the T-200G variant causes dysfunction of NMDA receptors consisting of the NR2B subunit and may be involved in the development of schizophrenia.
|
12476325 |
2002 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Association analysis of the genetic variants of the N-methyl D-aspartate receptor subunit 2b (NR2b) and treatment-refractory schizophrenia in the Chinese.
|
12824739 |
2003 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we observed increased expression of NMDA NR2B subunit transcripts, and decreased expression of all three associated postsynaptic density protein transcripts in schizophrenia.
|
15054476 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia.
|
15211626 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia.
|
15211626 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These findings suggest that the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.European Journal of Human Genetics (2005) 13, 807-814. doi:10.1038/sj.ejhg.5201418 Published online 20 April 2005.
|
15841096 |
2005 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray.
|
15841096 |
2005 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
LHGDN |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, we performed western blot analysis to determine whether protein levels of NMDA receptor subunits (NR1, NR2A, NR2B) and associated PSD proteins (NF-L, PSD95, SAP102) are altered in schizophrenia.
|
16762023 |
2006 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It is necessary to explain the inconsistency of these results and to clarify the contribution of the GRIN2B gene to schizophrenia.
|
17224684 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia.
|
17669510 |
2007 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found decreased NR1 expression in all three illnesses, decreased NR2A in schizophrenia and major depression, and decreased NR2C in schizophrenia.We found no changes of NR2B or NR2D.
|
18033238 |
2008 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we investigated whether expression of this NR2B-associated trafficking complex might be abnormal in schizophrenia.
|
20347576 |
2010 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variations in the N-methyl-d-aspartate receptor 2B subunit gene (GRIN2B) have been associated with schizophrenia, a psychiatric disorder associated with reduced left-hemispheric language dominance.
|
21827795 |
2011 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The significant associations and interactions were located at the 3' region of GRIN2B suggesting that genetic variation in this part of the gene may be involved in the pathophysiology of schizophrenia.
|
21919190 |
2011 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
One possible source of compromised glutamatergic function in SZ is decreased surface expression of GluN2B-containing NMDARs.
|
22781170 |
2012 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The present results support the hypothesis that rare de novo mutations in GRIN2A or GRIN2B can be associated with cases of sporadic SCZ or ASD, just as it has recently been described for the related neurodevelopmental disease intellectual disability.
|
22833210 |
2011 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation in the NR2B gene predicts reduced levels of the obligatory NR1 subunit, suggesting a novel mechanism by which the NR2B SNP may negatively influence other NMDAR subunit expression and reasoning ability in schizophrenia.
|
23070074 |
2013 |